Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30659-4
Abstract: Dysregulation in acetylation homeostasis has been implicated in the pathogenesis of the amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder. It is known that the acetylation of transcriptional factors regulates their activity. The acetylation state… read more here.
Keywords: rela; acetylation; acetylation state; sod1 g93a ... See more keywords
Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Brain"
DOI: 10.1186/s13041-021-00785-8
Abstract: Neuroinflammation by activated microglia and astrocytes plays a critical role in progression of amyotrophic lateral sclerosis (ALS). Interleukin-19 (IL-19) is a negative-feedback regulator that limits pro-inflammatory responses of microglia in an autocrine and paracrine manner,… read more here.
Keywords: sod1 g93a; motor function; mice; g93a mice ... See more keywords