Discovery of the First-in-Class G9a/GLP Covalent Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00652
Abstract: The highly homologous protein lysine methyltransferases G9a and GLP, which catalyze mono- and dimethylation of histone H3 lysine 9 (H3K9), have been implicated in various human diseases. To investigate functions of G9a and GLP in… read more here.
Keywords: glp; discovery first; first class; covalent ... See more keywords
Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.277046.122
Abstract: GLP (EHMT1) is a multifunctional protein, best known for its role as an H3K9me1 and H3K9me2 methyltransferase through its reportedly obligatory dimerization with G9A (EHMT2). Here, we investigate the role of GLP in the oocyte… read more here.
Keywords: glp; g9a; glp cdko; cko ... See more keywords
G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0300oc
Abstract: Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling of small pulmonary arteries (PAs) causing sustained elevation of PA pressure, right ventricular failure and death. Similar to cancer cells, PA smooth muscle cells (PASMCs),… read more here.
Keywords: pulmonary arterial; vascular remodeling; g9a glp; pulmonary vascular ... See more keywords
Histone Methyl Transferase G9a/GLP—A Novel Avenue in Pulmonary Arterial Hypertension Treatment?
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2023-0028ed
Abstract: Pulmonary arterial hypertension (PAH) is a rare but serious disease, with an estimated prevalence ranging from 10 to 52 cases per million (1). None of the currently available therapies has the ability to cure PAH,… read more here.
Keywords: pah; pasmcs; pulmonary arterial; g9a glp ... See more keywords