GAB1 is upregulated to promote anaplastic thyroid cancer cell migration through AKT-MDR1.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.101
Abstract: Anaplastic thyroid carcinoma (ATC) represents an undifferentiated, aggressive and highly metastatic form of thyroid cancer with high mortality. GAB1, through direct interaction with the kinase PI3K and phosphatase SHP2, is tightly involved in the activation… read more here.
Keywords: gab1; migration invasion; thyroid cancer; migration ... See more keywords
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.03.021
Abstract: The constitutively active Janus kinase 2 mutant Jak2-V617F is responsible for cytokine-independent growth of hematopoietic cells and the development of myeloproliferative neoplasms, such as polycythaemia vera and essential thrombocythaemia. Cells expressing Jak2-V617F exhibit constitutive STAT,… read more here.
Keywords: jak2 v617f; plasma membrane; gab1;
Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.14033
Abstract: Systemic sclerosis (SSc) is an autoimmune disease mainly characterized by persistent inflammation and fibrosis. The receptor tyrosine kinase (RTK) signal pathway plays an important role in the process of SSc, and Grb2‐associated binding protein (GAB)… read more here.
Keywords: inflammation fibrosis; ssc; gab1; systemic sclerosis ... See more keywords
Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d'origine nantais dependent GAB1/Src/β‐catenin pathway activation in a mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14622
Abstract: Blood brain barrier (BBB) disruption is an important contributor to brain edema and neurological deficits following intracerebral hemorrhage (ICH). Macrophage stimulating protein (MSP) is a hepatocyte growth factor‐like protein that mediates its functions via activating… read more here.
Keywords: gab1; msp; integrity; rhmsp ... See more keywords
Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162701
Abstract: As a hallmark of inflammatory bowel disease (IBD), elevated intestinal epithelial cell (IEC) death compromises the gut barrier, activating the inflammatory response and triggering more IEC death. However, the precise intracellular machinery that prevents IEC… read more here.
Keywords: necroptosis; ripk3 dependent; gab1; epithelial gab1 ... See more keywords
GAB1 as a Marker of Recurrence in Anterior Skull Base Meningioma
Sign Up to like & getrecommendations! Published in 2022 at "Neurosurgery"
DOI: 10.1227/neu.0000000000002209
Abstract: BACKGROUND: About one-third of anterior skull base meningiomas show Hedgehog pathway activation. We have recently identified GAB1 as a surrogate marker for Hedgehog pathway–activated meningiomas. OBJECTIVE: To determine the reproducibility and prognostic value of GAB1… read more here.
Keywords: gab1; anterior skull; gab1 marker; skull base ... See more keywords
Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor-induced endothelial progenitor cell proliferation and migration
Sign Up to like & getrecommendations! Published in 2019 at "PeerJ"
DOI: 10.7717/peerj.6675
Abstract: Objectives Grb2-associated binder 1 (Gab1), a scaffolding adaptor protein, plays an important role in transmitting key signals that control cell growth, migration, and function from multiple tyrosine kinase receptors. This study was designed to investigate… read more here.
Keywords: proliferation migration; gab1; migration; endothelial progenitor ... See more keywords