GAB2 regulates type 2 T helper cell differentiation in humans
Sign Up to like & getrecommendations! Published in 2017 at "Cytokine"
DOI: 10.1016/j.cyto.2017.04.027
Abstract: HighlightsIn vivo and in vitro polarized human T helper 2 cells highly expressed GAB2.GAB2 expression was regulated by IL‐4 and STAT6.GAB2 promoted IL‐4 and IL‐13 expression in human Th2 cells. Abstract Th2 cell differentiation involves… read more here.
Keywords: human th2; th2 cells; cell differentiation; gab2 ... See more keywords
Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01490-0
Abstract: Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicated Grb2-associated binder 2 (GAB2) as… read more here.
Keywords: gab2; acute myeloid; flt3 itd; myeloid leukemia ... See more keywords
Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02298-7
Abstract: GRB2-associated-binding protein 2 (Gab2) deletion has a preventive effect of on chronic liver inflammation and hepatocellular carcinoma. This study was aimed to elaborate Gab2-initiated immunoregulation during hepatocarcinogenesis. Compared to wild-type group, liver-specific overexpression of Gab2… read more here.
Keywords: immunosuppression; hepatocellular carcinoma; mice; overexpression ... See more keywords
Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316153
Abstract: Supplemental Digital Content is available in the text. Objective: In response to inflammatory insult, endothelial cells express cell adhesion molecules and TF (tissue factor), leading to increased adhesion of leukocytes to the endothelium and activation… read more here.
Keywords: role; grb2 associated; gab2 grb2; gab2 ... See more keywords
A Novel TEK::GAB2 Gene Fusion in Pediatric Angiosarcoma of Pelvic soft Tissue: A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2024 at "Pediatric and Developmental Pathology"
DOI: 10.1177/10935266241279073
Abstract: Pediatric angiosarcoma of soft tissue, an extremely rare entity, remains poorly understood from a genetic standpoint. Herein, we present the case of a previously healthy 17-year-old girl with acute left hip pain. Subsequent magnetic resonance… read more here.
Keywords: fusion; angiosarcoma; gene; gab2 ... See more keywords
Recurrent Amplification of Chromosome 7 in Murine AML with Dnmt3aR878H and Npm1cA Mutations Identifies Gab2 As a Possible Therapeutic Target in AML
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-199837
Abstract: NPM1 and DNMT3A mutations co-occur much more frequently than expected by chance, with ~15% of AML samples containing mutations in both genes. This synergy is recapitulated in mouse models, where mice with either Dnmt3aR878H or… read more here.
Keywords: mice; dnmt3ar878h npm1ca; aml; chromosome ... See more keywords
miR-9 and miR-181a Target Gab2 to Inhibit the Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112152
Abstract: The incidence of liver cancer ranks seventh globally, with nearly half of all cases occurring in East Asia, but currently, there are very few drugs to treat it. Our previous studies demonstrated that the signal… read more here.
Keywords: proliferation migration; mir 181a; gab2; mir mir ... See more keywords