The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202503739
Abstract: The locus coeruleus (LC) noradrenergic (NA) neurons regulate pain and depression through their projections to various downstream nuclei. Although GABAergic (GABA) neurons in and near the LC (LC‐GABA neurons) provide inhibitory synaptic inputs to LC‐NA… read more here.
Keywords: projection; gaba neurons; pain depression; pain ... See more keywords
Activation of VTA GABA neurons disrupts reward seeking by altering temporal processing
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113292
Abstract: The role of ventral tegmental area (VTA) dopamine in reward, cue processing, and interval timing is well characterized. Using a combinatorial viral approach to target activating DREADDs (Designer Receptors Exclusively Activated by Designer Drugs, hM3D)… read more here.
Keywords: processing; vta gaba; gaba neurons; activation ... See more keywords
Amygdala GABA Neurons Project To vlPAG And mPFC
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DOI: 10.1016/j.ibror.2019.03.001
Abstract: Highlights • Single amygdala GABA neuron projects to both brain stem and cortex.• Bifurcating amygdala neurons may regulate emotions and muscle tone. read more here.
Keywords: neurons project; gaba neurons; project vlpag; amygdala gaba ... See more keywords
VTA monosynaptic connections by local glutamate and GABA neurons and their distinct roles in behavior
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DOI: 10.1038/s41467-025-63396-0
Abstract: The ventral tegmental area (VTA) dopamine neurons have been implicated in diverse behaviors. These VTAdopamine neurons are intermixed with neurons that co-transmit glutamate and GABA (VTAglutamate-GABA), transmit glutamate (VTAglutamate-only) or GABA (VTAGABA-only). In dual recombinase… read more here.
Keywords: glutamate gaba; vtaglutamate neurons; gaba neurons; gaba ... See more keywords
Activity of GABA neurons in the zona incerta and ventral lateral periaqueductal grey is biased towards sleep.
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac306
Abstract: STUDY OBJECTIVES Because in various brain regions the activity of GABA neurons is largely unknown, we measured in-vivo changes in calcium fluorescence in GABA neurons in the zona incerta (ZI) and the ventral lateral periaqueductal… read more here.
Keywords: incerta ventral; gaba neurons; neurons zona; zona incerta ... See more keywords
Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons
Sign Up to like & getrecommendations! Published in 2025 at "Addiction Biology"
DOI: 10.1111/adb.70104
Abstract: Identifying shared neural mechanisms influenced by diverse classes of drugs of abuse is essential for understanding addiction and for developing broad-spectrum treatments for substance use disorders. Previous studies indicate that many drugs of abuse increase… read more here.
Keywords: chloride homeostasis; vta; gaba neurons; chloride ... See more keywords
Connexin‐36‐positive gap junctions in ventral tegmental area GABA neurons sustain opiate dependence
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.16366
Abstract: Drug dependence is characterized by a switch in motivation wherein a positively reinforcing substance can become negatively reinforcing. Put differently, drug use can transform from a form of pleasure‐seeking to a form of relief‐seeking. Ventral… read more here.
Keywords: gaba neurons; dependence; drug; gap ... See more keywords
GHSR in a subset of GABA neurons controls food deprivation-induced hyperphagia in male mice.
Sign Up to like & getrecommendations! Published in 2024 at "Endocrinology"
DOI: 10.1210/endocr/bqae061
Abstract: The growth hormone secretagogue receptor (GHSR), primarily known as the receptor for the hunger hormone ghrelin, potently controls food intake, yet the specific Ghsr-expressing cells mediating the orexigenic effects of this receptor remain incompletely characterized.… read more here.
Keywords: mice; ghsr; food; gaba neurons ... See more keywords
Parallel Gene Expression Changes in Ventral Midbrain Dopamine and GABA Neurons during Normal Aging
Sign Up to like & getrecommendations! Published in 2025 at "eNeuro"
DOI: 10.1523/eneuro.0107-25.2025
Abstract: The consequences of aging can vary dramatically between different brain regions and cell types. In the ventral midbrain, dopaminergic neurons develop physiological deficits with normal aging that likely convey susceptibility to neurodegeneration. While nearby GABAergic… read more here.
Keywords: gaba neurons; gene expression; ventral midbrain; dopamine gaba ... See more keywords
Upregulation of nAChRs and Changes in Excitability on VTA Dopamine and GABA Neurons Correlates to Changes in Nicotine-Reward-Related Behavior
Sign Up to like & getrecommendations! Published in 2020 at "eNeuro"
DOI: 10.1523/eneuro.0189-20.2020
Abstract: Abstract Previous reports indicate that nicotine reward is mediated through α4β2*, α6β2*, and α4α6β2* nicotinic acetylcholine receptors (nAChRs; * indicates that additional nAChR subunits may be present). Little is known about α4α6β2* nAChR involvement in… read more here.
Keywords: nicotine reward; gaba neurons; related behavior; reward related ... See more keywords
Ventral Tegmental Area GABA Neurons Are Resistant to GABA(A) Receptor-Mediated Inhibition During Ethanol Withdrawal
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00131
Abstract: The neural mechanisms underlying alcohol dependence are not well-understood. GABAergic neurons in the ventral tegmental area (VTA) are a relevant target for ethanol. They are inhibited by ethanol at physiologically-relevant levels in vivo and display… read more here.
Keywords: vta gaba; gaba neurons; gaba; ethanol ... See more keywords