Magnetic Resonance Imaging Features of GABA-A Receptor Antibody-Mediated Encephalitis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.5197
Abstract: This case report describes a patient with status epilepticus and neuroimaging features of fleeting T2 fluid-attenuated inversion recovery hyperintense lesions on magnetic resonance imaging. read more here.
Keywords: magnetic resonance; features gaba; resonance imaging; imaging features ... See more keywords
Important amino acids for function of the insect Rdl GABA receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.6121
Abstract: BACKGROUND Insect Rdl GABA receptor is an important insecticide target. To design a novel insecticide, studies on the structures of homologous pentameric ligand-gated ion channels provide information about important amino acids that are necessary for… read more here.
Keywords: receptor; drosophila rdl; gaba receptor; rdl gaba ... See more keywords
GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4864-1
Abstract: RationaleGR3027 is a novel small molecule GABA-A receptor-modulating steroid antagonist, which in non-clinical studies has shown promise for treatment of human disorders due to allosteric over-activation of GABA-A receptors by neurosteroids, such as allopregnanolone. We… read more here.
Keywords: brain function; gaba receptor; gr3027; allopregnanolone induced ... See more keywords
GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1158-x
Abstract: GABA-B receptors are important for Schwann cell (SC) commitment to a non-myelinating phenotype during development. However, the P0-GABA-B1fl/fl conditional knockout mice, lacking the GABA-B1 receptor specifically in SCs, also presented axon modifications, suggesting SC non-autonomous… read more here.
Keywords: schwann; vitro; gaba receptor; gaba ... See more keywords
Acupuncture suppresses intravenous methamphetamine self-administration through GABA receptor’s mediation
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.10.015
Abstract: OBJECTIVES Methamphetamine is one of the widely abused drugs. In spite of a number of studies, there is still little successful therapy to suppress the methamphetamine abuse. Acupuncture has shown to attenuate the reinforcing effects… read more here.
Keywords: self administration; gaba receptor; methamphetamine; acupuncture ... See more keywords
Optical Regulation of GABA Receptor by Visible Light via Azobenzene-Phenylpyrazole.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01463
Abstract: Photopharmacology provides superior temporal and spatial resolution for the study of biological functions of γ-aminobutyric acid receptors (GABARs), and photopharmacology based on GABARs has significantly advanced the research of neurons and cells. Herein, we reported… read more here.
Keywords: receptor visible; gaba receptor; optical regulation; visible light ... See more keywords
2-(4-Fluorophenyl)-1H-benzo[d]imidazole as a Promising Template for the Development of Metabolically Robust, α1β2γ2GABA-A Receptor-Positive Allosteric Modulators
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00800
Abstract: Modulation of α1β2γ2GABA-A receptor subpopulation expressed in the basal ganglia region is a conceptually novel mode of pharmacological strategy that offers prospects to tackle a variety of neurological dysfunction. Although clinical findings provided compelling evidence… read more here.
Keywords: 2gaba receptor; gaba receptor; allosteric modulators; fluorophenyl benzo ... See more keywords
Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99008-2
Abstract: Non-alcoholic steatohepatitis (NASH) is a rising health challenge, with no approved drugs. We used a computational drug repositioning strategy to uncover a novel therapy for NASH, identifying a GABA-B receptor agonist, AZD3355 (Lesogaberan) previously evaluated… read more here.
Keywords: non alcoholic; receptor agonist; agonist azd3355; azd3355 lesogaberan ... See more keywords
Decreased GABA-A Receptor Binding in Association With β-Lactam Antibiotic Use.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000002811
Abstract: β-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors, but it has not been demonstrated in humans in vivo. We report images of a [C]Ro15-4513… read more here.
Keywords: decreased gaba; binding association; receptor binding; receptor ... See more keywords
Furosemide suppresses ileal and colonic contractility via interactions with GABA‐A receptor in mice
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12824
Abstract: The loop diuretic furosemide has an action to inhibit Na+–K+–2Cl− co‐transporter at the thick ascending limb of Henle's loop resulting in diuresis. Furosemide also has the non‐diuretic effects by binding to GABA‐A receptor which may… read more here.
Keywords: furosemide; gaba receptor; contraction; receptor ... See more keywords
Differential protein expression of GABA A receptor alpha 1 subunit and calbindin in rat spermatozoa associated with proteomic analysis in testis following methamphetamine administration
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0273888
Abstract: Methamphetamine (METH) can induce spermatogenesis impairment, testicular apoptosis, and abnormal sperm quality. It also promotes changes in the expression of receptors for sex hormones and neurotransmitters, including GABA receptors in the testis. Proteomic assessment focusing… read more here.
Keywords: gaba receptor; calcium; calbindin; expression ... See more keywords