Magnetic Resonance Imaging Features of GABA-A Receptor Antibody-Mediated Encephalitis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.5197
Abstract: This case report describes a patient with status epilepticus and neuroimaging features of fleeting T2 fluid-attenuated inversion recovery hyperintense lesions on magnetic resonance imaging. read more here.
Keywords: magnetic resonance; features gaba; resonance imaging; imaging features ... See more keywords
Important amino acids for function of the insect Rdl GABA receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.6121
Abstract: BACKGROUND Insect Rdl GABA receptor is an important insecticide target. To design a novel insecticide, studies on the structures of homologous pentameric ligand-gated ion channels provide information about important amino acids that are necessary for… read more here.
Keywords: receptor; drosophila rdl; gaba receptor; rdl gaba ... See more keywords
GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4864-1
Abstract: RationaleGR3027 is a novel small molecule GABA-A receptor-modulating steroid antagonist, which in non-clinical studies has shown promise for treatment of human disorders due to allosteric over-activation of GABA-A receptors by neurosteroids, such as allopregnanolone. We… read more here.
Keywords: brain function; gaba receptor; gr3027; allopregnanolone induced ... See more keywords
GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1158-x
Abstract: GABA-B receptors are important for Schwann cell (SC) commitment to a non-myelinating phenotype during development. However, the P0-GABA-B1fl/fl conditional knockout mice, lacking the GABA-B1 receptor specifically in SCs, also presented axon modifications, suggesting SC non-autonomous… read more here.
Keywords: schwann; vitro; gaba receptor; gaba ... See more keywords
Acupuncture suppresses intravenous methamphetamine self-administration through GABA receptor’s mediation
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.10.015
Abstract: OBJECTIVES Methamphetamine is one of the widely abused drugs. In spite of a number of studies, there is still little successful therapy to suppress the methamphetamine abuse. Acupuncture has shown to attenuate the reinforcing effects… read more here.
Keywords: self administration; gaba receptor; methamphetamine; acupuncture ... See more keywords
Optical Regulation of GABA Receptor by Visible Light via Azobenzene-Phenylpyrazole.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01463
Abstract: Photopharmacology provides superior temporal and spatial resolution for the study of biological functions of γ-aminobutyric acid receptors (GABARs), and photopharmacology based on GABARs has significantly advanced the research of neurons and cells. Herein, we reported… read more here.
Keywords: receptor visible; gaba receptor; optical regulation; visible light ... See more keywords
N318L Blocks the Interaction of Fluralaner but Not Broflanilide or Fipronil with the Insect GABA Receptor In Vivo.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c06478
Abstract: Fluralaner is a novel insecticide targeting the ionotropic GABA receptor (GABAR) subunit, RDL. A recent study revealed that N316L, a substitution of asparagine (N) with leucine (L), in the second transmembrane (M2)-spanning region reduced the… read more here.
Keywords: vivo; fluralaner; gaba receptor; broflanilide fipronil ... See more keywords
2-(4-Fluorophenyl)-1H-benzo[d]imidazole as a Promising Template for the Development of Metabolically Robust, α1β2γ2GABA-A Receptor-Positive Allosteric Modulators
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00800
Abstract: Modulation of α1β2γ2GABA-A receptor subpopulation expressed in the basal ganglia region is a conceptually novel mode of pharmacological strategy that offers prospects to tackle a variety of neurological dysfunction. Although clinical findings provided compelling evidence… read more here.
Keywords: 2gaba receptor; gaba receptor; allosteric modulators; fluorophenyl benzo ... See more keywords
Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99008-2
Abstract: Non-alcoholic steatohepatitis (NASH) is a rising health challenge, with no approved drugs. We used a computational drug repositioning strategy to uncover a novel therapy for NASH, identifying a GABA-B receptor agonist, AZD3355 (Lesogaberan) previously evaluated… read more here.
Keywords: non alcoholic; receptor agonist; agonist azd3355; azd3355 lesogaberan ... See more keywords
Decreased GABA-A Receptor Binding in Association With β-Lactam Antibiotic Use.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000002811
Abstract: β-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors, but it has not been demonstrated in humans in vivo. We report images of a [C]Ro15-4513… read more here.
Keywords: decreased gaba; binding association; receptor binding; receptor ... See more keywords
Furosemide suppresses ileal and colonic contractility via interactions with GABA‐A receptor in mice
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12824
Abstract: The loop diuretic furosemide has an action to inhibit Na+–K+–2Cl− co‐transporter at the thick ascending limb of Henle's loop resulting in diuresis. Furosemide also has the non‐diuretic effects by binding to GABA‐A receptor which may… read more here.
Keywords: furosemide; gaba receptor; contraction; receptor ... See more keywords