GABA Receptors and the Pharmacology of Sleep.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_56
Abstract: Current GABAergic sleep-promoting medications were developed pragmatically, without making use of the immense diversity of GABAA receptors. Pharmacogenetic experiments are leading to an understanding of the circuit mechanisms in the hypothalamus by which zolpidem and… read more here.
Keywords: gaba receptors; pharmacology; gabaa receptors; receptors pharmacology ... See more keywords
Electrophysiology of ionotropic GABA receptors
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03846-2
Abstract: GABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and diverse roles GABAA receptors play in the regulation of neuronal… read more here.
Keywords: electrophysiology ionotropic; gaba receptors; ionotropic gaba; gabaa receptors ... See more keywords
GABAergic regulation of locomotion before and during an ethanol exposure in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113369
Abstract: Ethanol at low doses induces a locomotor stimulant response across a range of phylogenetically diverse species. In rodents, this response is commonly used as an index of ethanol's disinhibitory, anxiolytic, or reinforcing effects, and its… read more here.
Keywords: gaba receptors; locomotion; ionotropic gaba; drosophila melanogaster ... See more keywords
GABAergic signalling in modulation of dental pain.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174958
Abstract: Dental pain is a common complaint in patients undergoing endodontic treatment. Despite continuous efforts to develop new pain management strategies and improved treatment approaches, dental pain management remains a continuous challenge to clinicians. Understanding pain… read more here.
Keywords: gaba receptors; signalling modulation; dental pain; pain ... See more keywords
WITHDRAWN: Developmental regulation and lateralization of GABA receptors in the rat hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Developmental Neuroscience"
DOI: 10.1016/j.ijdevneu.2019.01.002
Abstract: GABA is the chief inhibitory neurotransmitter in the adult brain. However, in the developing brain it acts as an excitatory transmitter causing depolarization. Thereby, activates calcium-dependent processes that are crucial for brain development. Accordingly, GABA… read more here.
Keywords: rat hippocampus; brain; development; gaba receptors ... See more keywords
Exploring the Interaction Mechanism of Desmethyl-broflanilide in Insect GABA Receptors and Screening Potential Antagonists by In Silico Simulations.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c05728
Abstract: Broflanilide, a novel insecticide, is classified as a negative allosteric modulator (NAM) of insect γ-aminobutyric acid (GABA) receptors (GABARs) as desmethyl-broflanilide (DMBF) allosterically inhibits the GABA-induced responses. The G277M mutation of the Drosophila melanogaster GABAR… read more here.
Keywords: dmbf; insect gabars; mechanism; gaba receptors ... See more keywords
Activation of GABA-B receptors results in excitatory modulation of calyx terminals in rat semicircular canal cristae.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurophysiology"
DOI: 10.1152/jn.00243.2020
Abstract: Previous studies have found GABA in vestibular end organs. However, existence of GABA receptors or possible GABAergic effects on vestibular nerve afferents has not been investigated. The current study was conducted to determine whether activation… read more here.
Keywords: gaba receptors; effect; gaba; activation gaba ... See more keywords
Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.134685
Abstract: Mechanical, thermal, and chemical pain sensation is conveyed by primary nociceptors, a subset of sensory afferent neurons. The intracellular regulation of the primary nociceptive signal is an area of active study. We report here the… read more here.
Keywords: sensory neurons; mechanical nociception; nociception; regulation ... See more keywords
Activation of GABA(A) receptors inhibits T cell proliferation
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DOI: 10.1371/journal.pone.0251632
Abstract: Background The major sites for fast synaptic inhibition in the central nervous system (CNS) are ion channels activated by γ-aminobutyric acid (GABA). These receptors are referred as GABA(A) receptors (GABA(A)R). Recent evidence indicates a role… read more here.
Keywords: cell proliferation; gaba; activation; gaba receptors ... See more keywords
Ascorbic acid antagonizes the sedative effect of diazepam possibly through inhibition of GABA(Aρ₁) and GABA(B1) receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2020.66.4.3
Abstract: Gamma-aminobutyric acid (GABA) receptors belong to a ligand-gated ion channels family and are markedly expressed at the axon terminals of retinal bipolar cells. Ascorbic acid (AA), a known and vital antioxidant in the brain can… read more here.
Keywords: gaba receptors; ascorbic acid; sedative effect; gaba ... See more keywords
Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170613075736
Abstract: BACKGROUND γ-Aminobutyric acid (GABA) receptors play a central role in fast inhibitory neurotransmission in insects. Several classes of insecticides targeting insect GABA-gated chloride channels have been developed. The important resistant to dieldrin GABA receptor subunit… read more here.
Keywords: gaba receptors; gated chloride; insecticides targeting; gaba ... See more keywords