Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101552
Abstract: Summary Trigeminal neuralgia (TN) is a common, debilitating neuropathic face pain syndrome often resistant to therapy. The familial clustering of TN cases suggests that genetic factors play a role in disease pathogenesis. However, no unbiased,… read more here.
Keywords: neuronal ion; ion transport; gaba signaling; exome ... See more keywords
GABA signaling: A route to new pancreatic β cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Research"
DOI: 10.1038/cr.2017.20
Abstract: An ability to convert between pancreatic islet cell types may provide a new approach to replace insulin-secreting β cells destroyed by autoimmune attack in Type 1 diabetes. Two papers, which have recently appeared in Cell,… read more here.
Keywords: new pancreatic; gaba signaling; route new; pancreatic cells ... See more keywords
GABA Signaling in Plants - Targeting the Missing Pieces of the Puzzle.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of experimental botany"
DOI: 10.1093/jxb/eraa358
Abstract: Plant adaptation to the unstable environment relies on their ability to sense their surroundings, to generate and transmit corresponding signals to different parts of the plant, which evoke changes necessary for optimizing growth and defense… read more here.
Keywords: plants targeting; gaba signaling; pieces puzzle; signaling plants ... See more keywords
Cardiovascular deconditioning increases GABA signaling in the nucleus tractus solitarii.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00102.2022
Abstract: The nucleus tractus solitarii (nTS) is the major integrative brainstem region for autonomic modulation and processing of cardiovascular reflexes. GABA and glutamate are the main inhibitory and excitatory neurotransmitters, respectively, within this nucleus. Alterations in… read more here.
Keywords: nucleus tractus; tractus solitarii; gaba signaling; cardiovascular deconditioning ... See more keywords
KCC2 Much Chloride Might Not Be the Only Problem
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Currents"
DOI: 10.1177/1535759719890333
Abstract: KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction With Task-3 Channels Goutierre M, Al Awabdh S, Donneger F, et al. Cell Rep. 2019;28(1):91-103.e7. doi:10.1016/j.celrep.2019.06.001. PMID: 31269453. KCC2 regulates neuronal transmembrane chloride gradients and thereby… read more here.
Keywords: gaba signaling; chloride; kcc2 much; kcc2 ... See more keywords
Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Brain"
DOI: 10.1186/s13041-021-00881-9
Abstract: Light is a powerful external cue modulating the biological rhythm of internal clock neurons in the suprachiasmatic nucleus (SCN). GABA signaling in SCN is critically involved in this process. Both phasic and tonic modes of… read more here.
Keywords: gaba signaling; scn; gaba; suprachiasmatic nucleus ... See more keywords