Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects
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DOI: 10.1007/s11064-020-03017-y
Abstract: Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the… read more here.
Keywords: bgt1; inhibition; gaba transporter; anti seizure ... See more keywords
GABA transporter sustains IL-1β production in macrophages
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DOI: 10.1126/sciadv.abe9274
Abstract: GAT2 links metabolism to DNA methylation to orchestrate macrophage-dependent inflammation. Accumulating evidence shows that nervous system governs host immune responses; however, how γ-aminobutyric acid (GABA)ergic system shapes the function of innate immune cells is poorly… read more here.
Keywords: gat2 deficiency; transporter sustains; gaba transporter; transporter ... See more keywords
Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders
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DOI: 10.3389/fmolb.2022.834498
Abstract: The human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) is the first member of the solute carrier 6 (SLC6) protein superfamily. GAT-1 (SLC6A1) is one of the main GABA transporters in the central nervous system. Its… read more here.
Keywords: clinical repercussions; gaba transporter; transporter; molecular clinical ... See more keywords
Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants
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DOI: 10.3389/fnins.2022.1074427
Abstract: Mutations in the human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) can instigate myoclonic-atonic and other generalized epilepsies in the afflicted individuals. We systematically examined fifteen hGAT-1 disease variants, all of which dramatically reduced or completely… read more here.
Keywords: gaba transporter; model unraveling; gaba; melanogaster model ... See more keywords
Experimental and Bioinformatic Insights into the Effects of Epileptogenic Variants on the Function and Trafficking of the GABA Transporter GAT-1
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DOI: 10.3390/ijms24020955
Abstract: In this article, we identified a novel epileptogenic variant (G307R) of the gene SLC6A1, which encodes the GABA transporter GAT-1. Our main goal was to investigate the pathogenic mechanisms of this variant, located near the… read more here.
Keywords: gat; gaba transporter; transporter; permeation pathway ... See more keywords