LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "gaba transporter" as a keyword



Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects

Sign Up to like & get
recommendations! Published in 2020 at "Neurochemical Research"

DOI: 10.1007/s11064-020-03017-y

Abstract: Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the… read more here.

Keywords: bgt1; inhibition; gaba transporter; anti seizure ... See more keywords

Molecular basis of human GABA transporter 3 inhibition

Sign Up to like & get
recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-59066-w

Abstract: γ-Aminobutyric acid (GABA) transporters (GATs) are sodium- and chloride-dependent transporters that mediate the reuptake of the inhibitory neurotransmitter GABA after its release from synaptic vesicles. GAT3 transports GABA from the synaptic cleft into astrocytes and… read more here.

Keywords: inhibition; gaba transporter; gat3; snap 5114 ... See more keywords

GABA transporter sustains IL-1β production in macrophages

Sign Up to like & get
recommendations! Published in 2021 at "Science Advances"

DOI: 10.1126/sciadv.abe9274

Abstract: GAT2 links metabolism to DNA methylation to orchestrate macrophage-dependent inflammation. Accumulating evidence shows that nervous system governs host immune responses; however, how γ-aminobutyric acid (GABA)ergic system shapes the function of innate immune cells is poorly… read more here.

Keywords: gat2 deficiency; transporter sustains; gaba transporter; transporter ... See more keywords

Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2022.834498

Abstract: The human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) is the first member of the solute carrier 6 (SLC6) protein superfamily. GAT-1 (SLC6A1) is one of the main GABA transporters in the central nervous system. Its… read more here.

Keywords: clinical repercussions; gaba transporter; transporter; molecular clinical ... See more keywords

Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants

Sign Up to like & get
recommendations! Published in 2023 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2022.1074427

Abstract: Mutations in the human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) can instigate myoclonic-atonic and other generalized epilepsies in the afflicted individuals. We systematically examined fifteen hGAT-1 disease variants, all of which dramatically reduced or completely… read more here.

Keywords: gaba transporter; model unraveling; gaba; melanogaster model ... See more keywords

Experimental and Bioinformatic Insights into the Effects of Epileptogenic Variants on the Function and Trafficking of the GABA Transporter GAT-1

Sign Up to like & get
recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24020955

Abstract: In this article, we identified a novel epileptogenic variant (G307R) of the gene SLC6A1, which encodes the GABA transporter GAT-1. Our main goal was to investigate the pathogenic mechanisms of this variant, located near the… read more here.

Keywords: gat; gaba transporter; transporter; permeation pathway ... See more keywords

Structural Studies of the Taurine Transporter: A Potential Biological Target from the GABA Transporter Subfamily in Cancer Therapy

Sign Up to like & get
recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25137339

Abstract: The taurine transporter (TauT, SLC6A6) is a member of the solute carrier 6 (SLC6) family, which plays multiple physiological roles. The SLC6 family is divided into four subfamilies: GABA (γ-aminobutyric acid), monoamine, glycine and neutral… read more here.

Keywords: cancer; gaba transporter; structural studies; taurine transporter ... See more keywords