GABAA and GABAB receptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24368
Abstract: The subthalamic nucleus (STN) is a critical excitatory signaling center within the basal ganglia circuitry. The activity of subthalamic neurons is tightly controlled by upstream inhibitory signaling centers in the basal ganglia. In this study,… read more here.
Keywords: subthalamic nucleus; gabaa gabab; receptor subunits; receptor ... See more keywords
GABAA Receptors in the Mongolian Gerbil: a PET Study Using [18F]Flumazenil to Determine Receptor Binding in Young and Old Animals
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-019-01371-0
Abstract: PurposePlastic changes in the central auditory system involving the GABAergic system accompany age-related hearing loss. Such processes can be investigated with positron emission tomography (PET) imaging using [18F]flumazenil ([18F]FMZ). Here, [18F]FMZ PET-based modeling approaches allow… read more here.
Keywords: pet; using 18f; receptor; gabaa ... See more keywords
Dopamine Regulation of GABAA Receptors Contributes to Light/Dark Modulation of the ON-Cone Bipolar Cell Receptive Field Surround in the Retina
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.07.063
Abstract: Cone bipolar cells are interneurons that receive synaptic input from cone photoreceptor cells and provide the output of the first synaptic layer of the retina. These cells exhibit center-surround receptive fields, a prototype of lateral… read more here.
Keywords: cell; cone bipolar; receptive field; cone ... See more keywords
Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.03.014
Abstract: In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here… read more here.
Keywords: affinity; human pancreatic; gabaa receptors; gaba ... See more keywords
Variations on a scaffold - Novel GABAA receptor modulators.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.07.008
Abstract: Allosteric ligands of GABAA receptors exist in many different chemotypes owing to their great usefulness as therapeutics, with benzodiazepines being among the best known examples. Many allosteric binding sites have been described, among them a… read more here.
Keywords: gabaa receptor; variations scaffold; novel gabaa; gabaa receptors ... See more keywords
Sevoflurane depresses neurons in the medial parabrachial nucleus by potentiating postsynaptic GABAA receptors and background potassium channels
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108249
Abstract: Despite persistent clinical use for over 170 years, the neuronal mechanisms by which general anesthetics produce hypnosis remain unclear. Previous studies suggest that anesthetics exert hypnotic effects by acting on endogenous arousal circuits. Recently, it… read more here.
Keywords: medial parabrachial; potassium; hypnosis; gabaa ... See more keywords
Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32733-3
Abstract: There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in… read more here.
Keywords: mouse models; disease; homotaurine; multiple sclerosis ... See more keywords
Sleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2096076
Abstract: Abstract Context The sleep-promoting activity of Nelumbo nucifera Gaertn. (Nymphaeaceae) alkaloids in leaves or seeds are well known. However, the sleep-promoting activity of the lotus rhizome (LE), which is used mainly as food, has not… read more here.
Keywords: nelumbo nucifera; gabaa; activity; promoting activity ... See more keywords
Presynaptic GABAA Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1
Sign Up to like & getrecommendations! Published in 2019 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhx364
Abstract: &NA; Fast inhibitory GABAergic transmission plays a fundamental role in neural circuits. Current theories of cortical function assume that fast GABAergic inhibition acts via GABAA receptors on postsynaptic neurons, while presynaptic effects of GABA depend… read more here.
Keywords: thalamocortical inputs; modulate thalamocortical; receptors modulate; gabaa receptors ... See more keywords
Blockade of α1 subtype GABAA receptors attenuates the development of tolerance to the antinociceptive effects of midazolam in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000614
Abstract: Benzodiazepines bind to and act on α1-3 and α5-containing GABAA receptors. Previous studies suggest that different GABAA receptor α-subtypes mediate the various behavioral effects of benzodiazepines, which raises the possibility of combining benzodiazepines with subtype-selective… read more here.
Keywords: gabaa receptors; gabaa receptor; tolerance; gabaa ... See more keywords
Sesquiterpenes and sesquiterpenoids harbor modulatory allosteric potential and affect inhibitory GABAA receptor function in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15469
Abstract: Naturally occurring compounds such as sesquiterpenes and sesquiterpenoids (SQTs) have been shown to modulate GABAA receptors (GABAARs). In this study, the modulatory potential of 11 SQTs at GABAARs was analyzed to characterize their potential neurotropic… read more here.
Keywords: sesquiterpenes sesquiterpenoids; harbor modulatory; sesquiterpenoids harbor; allosteric potential ... See more keywords