Rare variants in the GABAA receptor subunit ε identified in patients with a wide spectrum of epileptic phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1388
Abstract: Epilepsy belongs to a group of chronic and highly heterogeneous brain disorders. Many types of epilepsy and epileptic syndromes are caused by genetic factors. read more here.
Keywords: gabaa receptor; receptor subunit; variants gabaa; identified patients ... See more keywords
Identification and expression of a unique neonatal variant of the GABAA receptor α3 subunit
Sign Up to like & getrecommendations! Published in 2017 at "Brain Structure and Function"
DOI: 10.1007/s00429-017-1597-6
Abstract: The GABAA receptor provides the majority of inhibitory neurotransmission in the adult central nervous system but in immature brain is responsible for much of the excitatory drive, a requirement for normal brain development. It is… read more here.
Keywords: receptor; gabaa receptor; brain; receptor subunit ... See more keywords
Inactivation of the Ventral Pallidum by GABAA Receptor Agonist Promotes Non-rapid Eye Movement Sleep in Rats
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03040-z
Abstract: GABA, the most abundant inhibitory neurotransmitter in the brain, is closely linked with sleep and wakefulness. As the largest area input to the ventral pallidum (VP), the nucleus accumbens (NAc) has been confirmed to play… read more here.
Keywords: gabaa receptor; rapid eye; non rapid; receptor ... See more keywords
Association of GABAA Receptor Gene with Epilepsy Syndromes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1081-7
Abstract: GABA has always been an inviting target in the etiology and treatment of epilepsy. The GABRA1, GABRG2, and GABRD genes provide instructions for making α1, ϒ2, and δ subunits of GABAA receptor protein respectively. GABAA… read more here.
Keywords: gabaa receptor; play important; polymorphism may; gene ... See more keywords
Cephalosporin antibiotics are weak blockers of GABAa receptor-mediated synaptic transmission in rat brain slices.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.008
Abstract: Cephalosporins are beta-lactam antibiotics that are extensively used in medical practice and are reported to cause epileptic seizures in some patients. The primary cause of cephalosporin-induced convulsions is believed to be their ability to block… read more here.
Keywords: brain slices; ceftriaxone; gabaa receptor; synaptic transmission ... See more keywords
Possible correlated variation of GABAA receptor α3 expression with hippocampal cholinergic neurostimulating peptide precursor protein in the hippocampus.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.010
Abstract: Cholinergic neural activation from the medial septal nucleus to hippocampus plays a crucial role in episodic memory as a regulating system for glutamatergic neural activation in the hippocampus. As a candidate regulating factor for acetylcholine… read more here.
Keywords: protein; gabaa receptor; hcnp; hippocampal cholinergic ... See more keywords
Autoimmune encephalitis with GABAA receptor antibodies in a 10-year-old girl
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2017.12.012
Abstract: Recent studies have indicated that some cases of nonparaneoplastic autoimmune encephalitis in children can be caused by a systemic autoimmune disorder that generates autoantibodies to cell membrane proteins. We describe the clinical features of a… read more here.
Keywords: autoimmune encephalitis; gabaa receptor; autoimmune; encephalitis ... See more keywords
Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABAA receptor subtypes.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2021.108985
Abstract: BACKGROUND To assess GABAA receptor subtypes involved in benzodiazepine tolerance and dependence, we evaluated the ability of subtype-selective and non-selective ligands to substitute for (i.e., produce "cross-tolerance") or precipitate withdrawal during chronic alprazolam treatment. METHODS… read more here.
Keywords: gabaa receptor; tolerance; chronic alprazolam; receptor subtypes ... See more keywords
Variations on a scaffold - Novel GABAA receptor modulators.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.07.008
Abstract: Allosteric ligands of GABAA receptors exist in many different chemotypes owing to their great usefulness as therapeutics, with benzodiazepines being among the best known examples. Many allosteric binding sites have been described, among them a… read more here.
Keywords: gabaa receptor; variations scaffold; novel gabaa; gabaa receptors ... See more keywords
Simultaneous quantification of EVT201, a novel partial positive allosteric GABAA receptor modulator, and its two metabolites in human plasma by UHPLC/MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.06.001
Abstract: HighlightsEVT201 is a novel partial GABAA receptor agonist to treat insomnia.A sensitive and accurate UHPLC‐MS/MS method was developed to determine EVT201 and its two metabolites in human plasma.The method was successfully applied to the sample… read more here.
Keywords: gabaa receptor; novel partial; human plasma; method ... See more keywords
A Japanese herbal medicine attenuates anxiety-like behavior through GABAA receptor and brain-derived neurotrophic factor expression in a rat model of premenstrual syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.11.003
Abstract: Inochinohaha White (IHW) is a Japanese herbal medicine for treating women with anxiety associated with premenstrual syndrome (PMS). In this study, we examined the effects of IHW on anxiety-like behavior in rats undergoing progesterone withdrawal… read more here.
Keywords: medicine; gabaa receptor; like behavior; anxiety like ... See more keywords