Presynaptic GABAB receptor inhibition sex dependently enhances fear extinction and attenuates fear renewal.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05831-w
Abstract: Anxiety and trauma-related disorders are highly prevalent worldwide, and are associated with altered associative fear learning. Despite the effectiveness of exposure therapy, which aims to reduce associative fear responses, relapse rates remain high. This is due,… read more here.
Keywords: gabab; renewal; extinction; inhibition ... See more keywords
Effect of coadministration of the GABAB agonist baclofen and the 5-HT2C agonist Ro60-0175 on the expression of amphetamine-induced locomotor sensitization
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Brain Research"
DOI: 10.1007/s00221-019-05540-z
Abstract: GABAB and 5-HT2C agonists are effective in attenuating the behavioral effects of psychostimulants. However, they induce adverse side effects when used in high doses. The previous evidence has suggested that the 5HT2C receptor activation effect… read more here.
Keywords: baclofen; gabab; agonist; ro60 0175 ... See more keywords
Stereological estimations and neurochemical characterization of neurons expressing GABAA and GABAB receptors in the rat pedunculopontine and laterodorsal tegmental nuclei
Sign Up to like & getrecommendations! Published in 2021 at "Brain Structure and Function"
DOI: 10.1007/s00429-021-02375-9
Abstract: To better understand GABAergic transmission at two targets of basal ganglia downstream projections, the pedunculopontine (PPN) and laterodorsal (LDT) tegmental nuclei, the anatomical localization of GABAA and GABAB receptors was investigated in both nuclei. Specifically,… read more here.
Keywords: gabab; tegmental nuclei; ppn ldt; gabaa gabab ... See more keywords
Presynaptic GABAB receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats
Sign Up to like & getrecommendations! Published in 2020 at "Brain Stimulation"
DOI: 10.1016/j.brs.2020.07.013
Abstract: Low-frequency electrical stimulation (LFES) of the brain is one of the promising methods for helping patients with pharmacoresistant epilepsy. However, the mechanism of the antiepileptic effect of LFES is still unclear. We applied electrophysiological and… read more here.
Keywords: gabab; model; antiepileptic effect; brain ... See more keywords
Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110255
Abstract: SUMMARY Inhibition of neurotransmitter release by neurotransmitter substances constitutes a fundamental means of neuromodulation. In contrast to well-delineated mechanisms that underlie inhibition of evoked release via suppression of voltage-gated Ca2+ channels, processes that underlie neuromodulatory… read more here.
Keywords: release; inhibition; neurotransmitter release; inhibition spontaneous ... See more keywords
F-phenibut (β-(4-Fluorophenyl)-GABA), a potent GABAB receptor agonist, activates an outward-rectifying K+ current and suppresses the generation of action potentials in mouse cerebellar Purkinje cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173437
Abstract: The GABA analog phenibut (β-Phenyl-GABA) is a GABAB receptor agonist that has been licensed for various uses in Russia. Phenibut is also available as a dietary supplement from online vendors worldwide, and previous studies have… read more here.
Keywords: gabab; agonist; rectifying current; phenibut ... See more keywords
Neuroprotective role of GABAB receptor modulation against streptozotocin-induced behavioral and biochemical abnormalities in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.054
Abstract: Stimulation as well as inhibition of GABAB (Gamma amino butyric acid) receptors has been reported to show beneficial effects in Alzheimer's disease (AD). Experimental evidences suggest that the use of GABAergic agents could influence learning… read more here.
Keywords: biochemical abnormalities; gabab; role gabab; abnormalities rats ... See more keywords
Differential sensitivity of presynaptic and postsynaptic GABAB receptors in rat ventrolateral periaqueductal gray
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000906
Abstract: The ventrolateral periaqueductal gray (PAG) in the midbrain plays a key role in the descending pain modulatory system. &ggr;-Aminobutyric acid type B (GABAB) receptors belong to a metabotropic receptor subfamily and mediate both presynaptic and… read more here.
Keywords: gabab; ventrolateral periaqueductal; presynaptic postsynaptic; postsynaptic gabab ... See more keywords
GABAB receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self‐administration of alcohol and cocaine
Sign Up to like & getrecommendations! Published in 2018 at "Addiction Biology"
DOI: 10.1111/adb.12688
Abstract: Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug‐induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug‐seeking behavior. To evaluate the impact of GABAB receptors… read more here.
Keywords: self administration; gabab; allosteric modulators; receptor ... See more keywords
Pre‐ and post‐synaptic modulation by GABAB receptors of rat neuroendocrine dopamine neurones
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12881
Abstract: The secretion of prolactin from the pituitary is negatively controlled by tuberoinfundibular dopamine (TIDA) neurones. The electrical properties of TIDA cells have recently been identified as a modulatory target of neurotransmitters and hormones in the… read more here.
Keywords: modulation gabab; modulation; tida neurones; gabab ... See more keywords
Activation of GABAB Receptor Suppresses Diabetic Neuropathic Pain through Toll-Like Receptor 4 Signaling Pathway in the Spinal Dorsal Horn
Sign Up to like & getrecommendations! Published in 2018 at "Mediators of Inflammation"
DOI: 10.1155/2018/6016272
Abstract: Diabetic neuropathic pain (DNP) is a prevalent complication in diabetes patients. Neuronal inflammation and activation of Toll-like receptor 4 (TLR4) are involved in the occurrence of DNP. However, the underlying mechanisms remain unclear. Downregulation of… read more here.
Keywords: gabab; tlr4 myd88; activation; receptor ... See more keywords