Effects of GABAB receptor positive allosteric modulator BHF177 and IRS‐1 on apoptosis of hippocampal neurons in rats with refractory epilepsy via the PI3K/Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11839
Abstract: The present study was conducted to determine the effects of the γ‐aminobutyric acid B (GABAB) receptor positive allosteric modulator BHF177 on refractory epilepsy (RE). An RE rat model was initially established via treatment with lithium‐pilocarpine.… read more here.
Keywords: pi3k akt; apoptosis; gabab receptor; hippocampal neurons ... See more keywords
GABAA and GABAB receptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24368
Abstract: The subthalamic nucleus (STN) is a critical excitatory signaling center within the basal ganglia circuitry. The activity of subthalamic neurons is tightly controlled by upstream inhibitory signaling centers in the basal ganglia. In this study,… read more here.
Keywords: subthalamic nucleus; gabaa gabab; receptor subunits; receptor ... See more keywords
GABAB receptor agonist baclofen promotes central nervous system remyelination
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24262
Abstract: Promoting remyelination is considered as a potential neurorepair strategy to prevent/limit the development of permanent neurological disability in patients with multiple sclerosis (MS). To this end, a number of clinical trials are investigating the potential… read more here.
Keywords: gabab receptor; opc differentiation; remyelination; agonist baclofen ... See more keywords
Activity‐dependent plasticity of presynaptic GABAB receptors at parallel fiber synapses
Sign Up to like & getrecommendations! Published in 2018 at "Synapse"
DOI: 10.1002/syn.22027
Abstract: Parallel fiber synapses in the cerebellum express a wide range of presynaptic receptors. However, presynaptic receptor expression at individual parallel fiber synapses is quite heterogeneous, suggesting physiological mechanisms regulate presynaptic receptor expression. We investigated changes… read more here.
Keywords: parallel fiber; fiber synapses; presynaptic gabab; receptor ... See more keywords
Taurine Promotes Retinal Ganglion Cell Survival Through GABAB Receptor Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1079-2_54
Abstract: Retinal ganglion cell (RGC) degeneration occurs in numerous retinal diseases, either as a primary process like in glaucoma, or secondary to photoreceptor loss and no efficient compound targeting directly RGC neuroprotection is yet available. We… read more here.
Keywords: retinal ganglion; ganglion cell; receptor; taurine ... See more keywords
GABAB receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.09.075
Abstract: The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis of lung tumor has been attracted more interest. GABAB receptor ligand-directed nanoparticles consisting of baclofen functionalized trimethyl chitosan (Bac-TMC) as polymeric… read more here.
Keywords: delivery; survivin sirna; receptor; ligand ... See more keywords
Structural Basis for Activation of the Heterodimeric GABAB Receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.09.023
Abstract: The neurotransmitter γ-aminobutyric acid (GABA) activates the metabotropic GABAB receptor to generate slow, prolonged inhibitory signals that regulate the neural circuitry. The GABAB receptor is an obligate heterodimeric G protein-coupled receptor (GPCR) comprised of GBR1… read more here.
Keywords: receptor; 7tm domain; activation; gabab receptor ... See more keywords
The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.11.016
Abstract: ABSTRACT Positive allosteric modulation of the GABAB receptor is a promising alternative to direct activation of the receptor as a therapeutic approach for treatment of addiction, chronic pain, anxiety, epilepsy, autism, Fragile X syndrome, and… read more here.
Keywords: novel potent; adx71441; positive allosteric; gabab receptor ... See more keywords
GABAB receptor, clozapine, and catatonia—a complex triad
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00889-y
Abstract: We were very pleased to read the article by Nair et al. [1], who rightly highlighted the pharmacological uniqueness of clozapine and hypothesized its action as a modulator of the gamma-aminobutyric acid B receptor (GABAB).… read more here.
Keywords: motor; gabab receptor; clozapine; catatonia ... See more keywords
Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABAB receptor-mediated inhibition of L-type calcium channels
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13599-3
Abstract: Spontaneous activity of serotonergic neurons of the dorsal raphe nucleus (DRN) regulates mood and motivational state. Potentiation of serotonergic function is one of the therapeutic strategies for treatment of various psychiatric disorders, such as major… read more here.
Keywords: gabab receptor; serotonergic neurons; spontaneous activity; mediated inhibition ... See more keywords
Effects of GABAB receptor activation on spatial cognitive function and hippocampal neurones in rat models of type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20171184
Abstract: The present study was conducted with the aim being to investigate the effect γ-aminobutyric acid type B (GABAB) receptor activation have on spatial cognitive function and hippocampal neurones found in the rat models of type… read more here.
Keywords: t2dm; hippocampal neurones; spatial cognitive; cognitive function ... See more keywords