GABAB Receptors in Neurodegeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2021_222
Abstract: GABA is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and acts via metabotropic GABAB receptors. Neurodegenerative diseases are a major burden and affect an ever increasing number of humans. The actual… read more here.
Keywords: receptors neurodegeneration; gabab receptors;
Presynaptic GABAB receptor inhibition sex dependently enhances fear extinction and attenuates fear renewal.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05831-w
Abstract: Anxiety and trauma-related disorders are highly prevalent worldwide, and are associated with altered associative fear learning. Despite the effectiveness of exposure therapy, which aims to reduce associative fear responses, relapse rates remain high. This is due,… read more here.
Keywords: gabab; renewal; extinction; inhibition ... See more keywords
Astrocytic GABAB Receptors in Mouse Hippocampus Control Responses to Behavioral Challenges through Astrocytic BDNF
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00474-x
Abstract: Major depressive disorder (MDD) is a common mood disorder that affects almost 20% of the global population. In addition, much evidence has implicated altered function of the gamma-aminobutyric acid (GABAergic) system in the pathophysiology of… read more here.
Keywords: hippocampus; astrocytic gabab; mouse hippocampus; receptors mouse ... See more keywords
Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychotics
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.09.019
Abstract: Abstract Recent preclinical studies point to muscarinic and GABAB receptors as novel therapeutic targets for the treatment of schizophrenia. This study was aimed to assess the role of muscarinic and GABAB receptor interactions in animal… read more here.
Keywords: muscarinic gabab; doi induced; drug; receptor ... See more keywords
Presynaptic GABAB receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats
Sign Up to like & getrecommendations! Published in 2020 at "Brain Stimulation"
DOI: 10.1016/j.brs.2020.07.013
Abstract: Low-frequency electrical stimulation (LFES) of the brain is one of the promising methods for helping patients with pharmacoresistant epilepsy. However, the mechanism of the antiepileptic effect of LFES is still unclear. We applied electrophysiological and… read more here.
Keywords: gabab; model; antiepileptic effect; brain ... See more keywords
Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09164-3
Abstract: GABAB receptors (GBRs) are key regulators of synaptic release but little is known about trafficking mechanisms that control their presynaptic abundance. We now show that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar… read more here.
Keywords: formation; complex formation; gbr; axonal trafficking ... See more keywords
Differential sensitivity of presynaptic and postsynaptic GABAB receptors in rat ventrolateral periaqueductal gray
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000906
Abstract: The ventrolateral periaqueductal gray (PAG) in the midbrain plays a key role in the descending pain modulatory system. &ggr;-Aminobutyric acid type B (GABAB) receptors belong to a metabotropic receptor subfamily and mediate both presynaptic and… read more here.
Keywords: gabab; ventrolateral periaqueductal; presynaptic postsynaptic; postsynaptic gabab ... See more keywords
Pre‐ and post‐synaptic modulation by GABAB receptors of rat neuroendocrine dopamine neurones
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12881
Abstract: The secretion of prolactin from the pituitary is negatively controlled by tuberoinfundibular dopamine (TIDA) neurones. The electrical properties of TIDA cells have recently been identified as a modulatory target of neurotransmitters and hormones in the… read more here.
Keywords: modulation gabab; modulation; tida neurones; gabab ... See more keywords
Brainstem activation of GABAB receptors in the nucleus tractus solitarius increases gastric motility
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.961042
Abstract: Background and aim Local GABAergic signaling in the dorsal vagal complex (DVC) is essential to control gastric function. While the inhibitory GABAA receptor action on motility in the DVC is well-documented, the role of the… read more here.
Keywords: brainstem; gastric motility; motility; gabab receptors ... See more keywords
Protein phosphatase 2A regulation of GABAB receptors normalizes ischemia-induced aberrant receptor trafficking and provides neuroprotection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1015906
Abstract: One major factor regulating the strength of GABAB receptor signaling and thereby neuronal excitability is the dynamic control of their cell surface expression. GABAB receptors are constitutively internalized and recycled back to the plasma membrane… read more here.
Keywords: cell surface; pp2a; gabab receptor; gabab receptors ... See more keywords
Keeping the Balance: GABAB Receptors in the Developing Brain and Beyond
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12040419
Abstract: The main neurotransmitter in the brain responsible for the inhibition of neuronal activity is γ-aminobutyric acid (GABA). It plays a crucial role in circuit formation during development, both via its primary effects as a neurotransmitter… read more here.
Keywords: keeping balance; brain; gabab receptors; balance gabab ... See more keywords