Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.024
Abstract: Excitation-inhibition (E-I) imbalance is considered a hallmark of various neurodevelopmental disorders, including schizophrenia and autism. How genetic risk factors disrupt coordinated glutamatergic and GABAergic synapse formation to cause an E-I imbalance is not well understood.… read more here.
Keywords: imbalance; risk; gabaergic; inhibition imbalance ... See more keywords
Downregulation of parvalbumin expression in the prefrontal cortex during adolescence causes enduring prefrontal disinhibition in adulthood
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0709-9
Abstract: The expression of the calcium binding protein parvalbumin (PV) has been observed in several cortical regions during development in a temporal pattern consistent with increased afferent-dependent activity. In the prefrontal cortex (PFC), PV expression appears… read more here.
Keywords: adolescence; gabaergic; expression; parvalbumin ... See more keywords
Ultrastructural, Molecular and Functional Mapping of GABAergic Synapses on Dendritic Spines and Shafts of Neocortical Pyramidal Neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral cortex"
DOI: 10.1093/cercor/bhy143
Abstract: The location of GABAergic synapses on dendrites is likely key for neuronal integration. In particular, inhibitory inputs on dendritic spines could serve to selectively veto or modulate individual excitatory inputs, greatly expanding the computational power… read more here.
Keywords: mapping; gabaergic; pyramidal neurons; ultrastructural molecular ... See more keywords
Insulin as a potent bidirectional regulator of GABAergic signalling in the hippocampus of an Alzheimer’s disease mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Acta Physiologica"
DOI: 10.1111/apha.13660
Abstract: Due to its fundamental role in balancing neuronal activity in the brain, GABAergic signaling is the target of a broad spectrum of regulations. Still, how the metabolic hormone insulin affects GABAergic signaling in the hippocampus… read more here.
Keywords: insulin; alzheimer disease; gabaergic; disease ... See more keywords
Kv4 channel expression and kinetics in GABAergic and non-GABAergic rNST neurons.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurophysiology"
DOI: 10.1152/jn.00396.2020
Abstract: The rostral nucleus of the solitary tract (rNST) serves as the first central relay in the gustatory system. In addition to synaptic interactions, central processing is also influenced by the ion-channel composition of individual neurons.… read more here.
Keywords: non gabaergic; kv4 channel; gabaergic non; rnst ... See more keywords