Propofol Protects Rat Hypoglossal Motoneurons in an In Vitro Model of Excitotoxicity by Boosting GABAergic Inhibition and Reducing Oxidative Stress
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.10.019
Abstract: In brainstem motor networks, hypoglossal motoneurons (HMs) play the physiological role of driving tongue contraction, an activity critical for inspiration, phonation, chewing and swallowing. HMs are an early target of neurodegenerative diseases like amyotrophic lateral… read more here.
Keywords: propofol; boosting gabaergic; excitotoxicity; inhibition ... See more keywords
APP modulates KCC2 expression and function in hippocampal GABAergic inhibition
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.20142
Abstract: Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in App knock-out (App-/-) animals, but the precise mechanism… read more here.
Keywords: app; inhibition; gabaergic inhibition; kcc2 expression ... See more keywords