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   Articles with "gabaergic interneurons" as a keyword



Generation of cerebral cortical GABAergic interneurons from pluripotent stem cells

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recommendations! Published in 2020 at "STEM CELLS"

DOI: 10.1002/stem.3252

Abstract: The cerebral cortex functions by the complex interactions of intrinsic and extrinsic neuronal activities, glial actions, and the effects of humoral factors. The intrinsic neuronal influences are mediated by two major subclasses: excitatory glutamatergic neurons… read more here.

Keywords: cortical gabaergic; generation; pluripotent stem; gabaergic interneurons ... See more keywords

Cajal-Retzius cells and GABAergic interneurons of the developing hippocampus: Close electrophysiological encounters of the third kind

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.07.028

Abstract: In contrast to the large number of studies investigating the electrophysiological properties and synaptic connectivity of hippocampal pyramidal neurons, granule cells, and GABAergic interneurons, much less is known about Cajal-Retzius cells. In this review article,… read more here.

Keywords: cajal retzius; retzius cells; cells gabaergic; retzius ... See more keywords
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Age-dependent decrease of GAD65/67 mRNAs but normal densities of GABAergic interneurons in the brain regions of Shank3-overexpressing manic mouse model

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recommendations! Published in 2017 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.04.016

Abstract: Dysfunction of inhibitory GABAergic interneurons is considered a major pathophysiological feature of various neurodevelopmental and neuropsychiatric disorders. The variants of SHANK3 gene, encoding a core scaffold protein of the excitatory postsynapse, have been associated with… read more here.

Keywords: gad65; shank3 transgenic; transgenic mice; mice ... See more keywords
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Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures

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recommendations! Published in 2017 at "Neuron"

DOI: 10.1016/j.neuron.2016.11.043

Abstract: GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which… read more here.

Keywords: dynamic cell; model; gabaergic interneurons; seizure ... See more keywords

The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex

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recommendations! Published in 2020 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2020.108180

Abstract: Antagonists of the group II metabotropic glutamate (mGlu) 2/3 receptors have been shown to have a rapid antidepressant effect. GABAergic interneurons play a crucial role in major depressive disorder (MDD) and possibly mediate the rapid… read more here.

Keywords: types gabaergic; synaptic activities; effect; mglu2 receptors ... See more keywords
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Long-term Reductions in the Population of GABAergic Interneurons in the Mouse Hippocampus following Developmental Ethanol Exposure

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recommendations! Published in 2018 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2018.05.003

Abstract: Developmental exposure to ethanol leads to a constellation of cognitive and behavioral abnormalities known as Fetal Alcohol Spectrum Disorders (FASDs). Many cell types throughout the central nervous system are negatively impacted by gestational alcohol exposure,… read more here.

Keywords: ethanol exposure; long term; exposure; developmental ethanol ... See more keywords

Clenbuterol reduces GABAergic transmission in prefrontal cortex layer 5/6 pyramidal neurons of juvenile rat via reducing action potentials firing frequency of GABAergic interneurons

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recommendations! Published in 2018 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.14248

Abstract: Beta‐adrenoceptors (β2‐ARs) have beneficial effects on prefrontal cortex (PFC) working memory, however, the cellular and molecular mechanisms are unclear yet. In this study, we probed the effect of β2‐AR‐selective agonist clenbuterol (Clen) on synaptic transmission… read more here.

Keywords: transmission; layer pyramidal; pyramidal neurons; gabaergic interneurons ... See more keywords

GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats

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recommendations! Published in 2024 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.16123

Abstract: Fear overgeneralization is widely accepted as a pathogenic marker of post‐traumatic stress disorder (PTSD). Recently, GABAergic interneurons have been regarded as key players in the regulation of fear memory. The role of hippocampal GABAergic interneurons… read more here.

Keywords: fear generalization; ptsd rats; gabaergic interneurons; ptsd ... See more keywords

Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations

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recommendations! Published in 2019 at "Molecular Brain"

DOI: 10.1186/s13041-019-0426-7

Abstract: Parkinson’s disease (PD) is associated with both motor and non-motor symptoms, including constipation, sensory neuropathy, depression, dementia and sleep disorder. Somatostatin (SST) is considered to be a modulator of GABAergic inhibitory transmission, and its levels… read more here.

Keywords: induced pluripotent; expression; pluripotent stem; derived induced ... See more keywords

Abnormalities in Cortical GABAergic Interneurons of the Primary Motor Cortex Caused by Lis1 (Pafah1b1) Mutation Produce a Non-drastic Functional Phenotype

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.769853

Abstract: LIS1 (PAFAH1B1) plays a major role in the developing cerebral cortex, and haploinsufficient mutations cause human lissencephaly type 1. We have studied morphological and functional properties of the cerebral cortex of mutant mice harboring a… read more here.

Keywords: gabaergic interneurons; lis1 pafah1b1; cortical gabaergic; phenotype ... See more keywords

HCN Channel Modulation of Synaptic Integration in GABAergic Interneurons in Malformed Rat Neocortex

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recommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2017.00109

Abstract: Cortical malformations are often associated with pharmaco-resistant epilepsy. Alterations in hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels have been shown to contribute to malformation associated hyperexcitability. We have recently demonstrated that expression of HCN channels… read more here.

Keywords: fast spiking; malformed rat; control; hcn ... See more keywords