Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis
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DOI: 10.1002/advs.202504406
Abstract: The peripheral immune system contributes to the development of sepsis‐induced cardiomyopathy. However, the underlying mechanisms linking central immune cells and neurons to sepsis‐induced cardiomyopathy remain to be clarified. Here, acute sepsis is induced by cecal… read more here.
Keywords: activation; gabaergic neuronal; necroptosis; sepsis induced ... See more keywords
Upregulation of Cdh1 in the trigeminal spinal subnucleus caudalis attenuates trigeminal neuropathic pain via inhibiting GABAergic neuronal apoptosis
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DOI: 10.1016/j.neuint.2019.104613
Abstract: Trigeminal neuropathic pain (TNP) remains a tremendous clinical challenge due to its elusive mechanisms. Previous studies showed that peripheral nerve injury facilitated a selective GABAergic neuronal apoptosis in the superficial dorsal horn and contributed to… read more here.
Keywords: apoptosis; neuronal apoptosis; neuropathic pain; trigeminal neuropathic ... See more keywords
0286 Alterations in Sleep Architecture Following Dual GABAergic Neuronal Ablation in the Parafacial Zone and Preoptic Area
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DOI: 10.1093/sleep/zsaf090.0286
Abstract: GABAergic neurotransmission plays a pivotal role in sleep regulation. Key sleep-promoting centers in the mammalian brain, such as the medullary parafacial zone (PZ) and the hypothalamic preoptic area (POA), rely on GABA to mediate their… read more here.
Keywords: mice; dual gabaergic; neuronal ablation; ablation ... See more keywords