Insights into the leveraging of GABAergic signaling in cancer therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6102
Abstract: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain of adult mammals. Several studies have demonstrated that the GABAergic system may regulate tumor development via GABA receptors, downstream cyclic adenosine monophosphate (cAMP) pathway,… read more here.
Keywords: insights leveraging; gabaergic signaling; cancer therapy; cancer ... See more keywords
GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3hi0720-431r
Abstract: Protective cytotoxic and proinflammatory cytokine responses by NK cells impact the outcome of infections by Toxoplasma gondii, a common parasite in humans and other vertebrates. However, T. gondii can also sequester within NK cells and… read more here.
Keywords: gaba; toxoplasma gondii; human murine; gondii ... See more keywords
Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.06.004
Abstract: Secondary generalized seizure (sGS) is a major source of disability in temporal lobe epilepsy (TLE) with unclear cellular/circuit mechanisms. Here we found that clinical TLE patients with sGS showed reduced volume specifically in the subiculum… read more here.
Keywords: lobe epilepsy; generalized seizure; gabaergic signaling; signaling subicular ... See more keywords
A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.60528
Abstract: Gamma-aminobutyric acid (GABA) serves diverse biological functions in prokaryotes and eukaryotes, including neurotransmission in vertebrates. Yet, the role of GABA in the immune system has remained elusive. Here, a comprehensive characterization of human and murine… read more here.
Keywords: system; mononuclear phagocytes; coccidian parasites; gabaergic signaling ... See more keywords