Adeno-associated viral overexpression of neuroligin 2 in the mouse hippocampus enhances GABAergic synapses and impairs hippocampal-dependent behaviors
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.12.052
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT The cell adhesion molecule neuroligin2 (NLGN2) regulates GABAergic synapse development, but its role in neural circuit function in the adult hippocampus is unclear. We investigated GABAergic synapses and… read more here.
Keywords: dependent behaviors; overexpression; hippocampus; adeno associated ... See more keywords
Activity-dependent development of GABAergic synapses
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.11.014
Abstract: In the brain, dendrites of pyramidal neurons contain intermingled excitatory and inhibitory synapses. Synaptic connections dynamically change during development and throughout our lifetime, yet the brain can properly maintain an optimal ratio of synaptic excitation… read more here.
Keywords: dependent development; gabaergic synapses; activity dependent; activity ... See more keywords
CB1 cannabinoid receptor-mediated plasticity of GABAergic synapses in the mouse insular cortex
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64236-5
Abstract: The insular cortex plays pivotal roles in taste learning. As cellular mechanisms of taste learning, long-term potentiation (LTP) at glutamatergic synapses is well studied. However, little is known about long-term changes of synaptic efficacy at… read more here.
Keywords: long term; gabaergic synapses; insular cortex; plasticity gabaergic ... See more keywords
Ultrastructural, Molecular and Functional Mapping of GABAergic Synapses on Dendritic Spines and Shafts of Neocortical Pyramidal Neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral cortex"
DOI: 10.1093/cercor/bhy143
Abstract: The location of GABAergic synapses on dendrites is likely key for neuronal integration. In particular, inhibitory inputs on dendritic spines could serve to selectively veto or modulate individual excitatory inputs, greatly expanding the computational power… read more here.
Keywords: mapping; gabaergic; pyramidal neurons; ultrastructural molecular ... See more keywords
Somatodendritic Release of Cholecystokinin Potentiates GABAergic Synapses Onto Ventral Tegmental Area Dopamine Cells
Sign Up to like & getrecommendations! Published in 2022 at "Biological Psychiatry"
DOI: 10.1101/2022.01.14.476405
Abstract: Neuropeptides are contained in nearly every neuron in the central nervous system and can be released from somatodendritic sites as well as from nerve terminals. Cholecystokinin (CCK), among the most abundant neuropeptides in the brain,… read more here.
Keywords: tegmental area; dopamine; gabaergic synapses; release ... See more keywords
Mechanisms of long-term plasticity of hippocampal GABAergic synapses
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297917030038
Abstract: Long-term potentiation and depression of synaptic transmission have been considered as cellular mechanisms of memory in studies conducted in recent decades. These studies were predominantly focused on mechanisms underlying plasticity at excitatory synapses. Nevertheless, normal… read more here.
Keywords: term; long term; mechanisms long; term plasticity ... See more keywords
DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002078
Abstract: Down syndrome (DS) is caused by the trisomy of human chromosome 21 (HSA21). A major challenge in DS research is to identify the HSA21 genes that cause specific symptoms. Down syndrome cell adhesion molecule (DSCAM)… read more here.
Keywords: dscam; gabaergic synapses; excessive gabaergic; triplication ... See more keywords