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   Articles with "gabaergic synaptic" as a keyword



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Double-edged GABAergic synaptic transmission in seizures: The importance of chloride plasticity

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.09.008

Abstract: GABAergic synaptic inhibition, which is a critical regulator of neuronal excitability, is closely involved in epilepsy. Interestingly, fast GABAergic transmission mediated by Cl- permeable GABAA receptors can bi-directionally exert both seizure-suppressing and seizure-promoting actions. Accumulating… read more here.

Keywords: synaptic transmission; gabaergic synaptic; chloride plasticity; pathology ... See more keywords

A conditional GABAergic synaptic vesicle marker for Drosophila

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recommendations! Published in 2022 at "Journal of Neuroscience Methods"

DOI: 10.1016/j.jneumeth.2022.109540

Abstract: BACKGROUND Throughout the animal kingdom, GABA is the principal inhibitory neurotransmitter of the nervous system. It is essential for maintaining the homeostatic balance between excitation and inhibition required for the brain to operate normally. Identification… read more here.

Keywords: marker; conditional gabaergic; vesicle marker; neurotransmitter phenotyping ... See more keywords
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Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons

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recommendations! Published in 2018 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2018.01.024

Abstract: NMDA-type ionotropic glutamate receptors (NMDARs) play an important role in the regulation of synapse development and function in the brain. Recently we have shown that NMDARs are critical for GABAergic synapse development in developing hippocampal… read more here.

Keywords: transmission two; synaptic transmission; gabaergic synaptic; development ... See more keywords
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Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons

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recommendations! Published in 2018 at "Epilepsia"

DOI: 10.1111/epi.13990

Abstract: Phenobarbital is the most commonly utilized drug for the treatment of neonatal seizures. The use of phenobarbital continues despite growing evidence that it exerts suboptimal seizure control and is associated with long‐term alterations in brain… read more here.

Keywords: exposure disrupts; phenobarbital exposure; neonatal phenobarbital; exposure ... See more keywords

The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction

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recommendations! Published in 2018 at "PLoS Genetics"

DOI: 10.1371/journal.pgen.1007263

Abstract: The C. elegans ortholog of mammalian calsyntenins, CASY-1, is an evolutionarily conserved type-I transmembrane protein that is highly enriched in the nervous system. Mammalian calsyntenins are strongly expressed at inhibitory synapses, but their role in… read more here.

Keywords: elegans neuromuscular; synaptic transmission; neuromuscular junction; gabaergic synaptic ... See more keywords
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Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord

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recommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2022.903087

Abstract: The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of nociceptive messages. Plastic changes in the properties of neuronal networks in the DH underlie the development of analgesia… read more here.

Keywords: synaptic transmission; modulation gabaergic; gabaergic synaptic; transmission ... See more keywords

Action of the Photochrome Glyght on GABAergic Synaptic Transmission in Mouse Brain Slices

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms231810553

Abstract: Glyght is a new photochromic compound described as an effective modulator of glycine receptors at heterologous expression, in brain slices and in zebrafish larvae. Glyght also caused weak inhibition of GABAA-mediated currents in a cell… read more here.

Keywords: brain slices; synaptic transmission; gabaergic synaptic; transmission ... See more keywords