Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.3680
Abstract: Importance Gabapentin has been increasingly used as part of a multimodal analgesia regimen to reduce opioid use in perioperative pain management. However, the safety of perioperative gabapentin use among older patients remains uncertain. Objective To… read more here.
Keywords: gabapentin use; among older; major surgery; perioperative gabapentin ... See more keywords
Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2018.3077
Abstract: Importance Optimal pharmacologic treatment for chronic sciatica (CS) is currently unclear. While gabapentin (GBP) and pregabalin (PGB) are both used to treat CS, equipoise exists. Nevertheless, pharmaceutical regulation authorities typically subsidize one drug over the… read more here.
Keywords: pain intensity; trial; gbp; pgb ... See more keywords
Descending Noradrenergic Inhibition: An Important Mechanism of Gabapentin Analgesia in Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-1756-9_8
Abstract: Gabapentinoids are effective in a wide range of animal pain models and in patients with neuropathic pain and has become one of first-line treatments for neuropathic pain. Because spinal plasticity and sensitization have been intensely… read more here.
Keywords: gabapentin analgesia; neuropathic pain; descending noradrenergic; gabapentin ... See more keywords
Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Urogynecology Journal"
DOI: 10.1007/s00192-021-05017-0
Abstract: Chronic pelvic pain (CPP) affects 2.1–24% of women, causing physical and psychological damage to women around the world. Based on the efficacy of gabapentin in the treatment of chronic pain, we conducted this study to… read more here.
Keywords: gabapentin; pain scores; pain; side effects ... See more keywords
Effect of gabapentin on sleep and delta and theta EEG power in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4888-6
Abstract: RationaleAdolescents and young adults with alcohol problems may also have sleep difficulties. However, whether these sleep problems are a result of a history of drinking or arise due to other comorbid disorders is difficult to… read more here.
Keywords: adult rats; power; vapor; sleep ... See more keywords
Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05587-9
Abstract: There are controversial reports on the effects of gabapentin in respect to psychotic symptoms. Prepulse inhibition of the acoustic startle response is an operational measure of sensorimotor gating. In laboratory rodents, deficits in sensorimotor gating… read more here.
Keywords: sleep deprivation; sensorimotor gating; deprivation; prepulse inhibition ... See more keywords
Effectiveness of gabapentin as a postoperative analgesic in children undergoing appendectomy
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Surgery International"
DOI: 10.1007/s00383-018-4274-9
Abstract: PurposeThough gabapentin is increasingly used as a perioperative analgesic, data regarding effectiveness in children are limited. The purpose of this study was to evaluate gabapentin as a postoperative analgesic in children undergoing appendectomy.MethodsA 12-month retrospective… read more here.
Keywords: gabapentin postoperative; gabapentin; children undergoing; postoperative analgesic ... See more keywords
A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain
Sign Up to like & getrecommendations! Published in 2021 at "Atencion Primaria"
DOI: 10.1016/j.aprim.2021.102144
Abstract: Aim This SR aims to assess the effectiveness of pregabalin and gabapentin on pain and disability caused by acute sciatica and the adverse events associated with their clinical use. Design Systematic review. Databases Electronic databases… read more here.
Keywords: pregabalin; systematic review; sciatica; adverse events ... See more keywords
Gabapentin drug misuse signals: A pharmacovigilance assessment using the FDA adverse event reporting system.
Sign Up to like & getrecommendations! Published in 2019 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2019.107709
Abstract: BACKGROUND Although there have been increasing reports of intentional gabapentin misuse, epidemiological evidence for the phenomenon is limited. The purpose of this study was to determine whether there are pharmacovigilance abuse signals for gabapentin. METHODS… read more here.
Keywords: reporting; drug; using fda; pharmacovigilance ... See more keywords
An algorithm to identify gabapentin misuse and/or abuse in administrative claims data.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2022.109429
Abstract: BACKGROUND Despite gabapentin's misuse and abuse potential and associated adverse events, few algorithms are available to detect gabapentin misuse and/or abuse in claims data. This study aims to develop an algorithm to identify gabapentin misuse… read more here.
Keywords: gabapentin; gabapentin misuse; algorithm identify; claims data ... See more keywords
Gabapentin attenuates intestinal inflammation: Role of PPAR-gamma receptor.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.172974
Abstract: Gabapentin is an anticonvulsant drug that is also used for post-herpetic neuralgia and neuropathic pain. Recently, gabapentin showed anti-inflammatory effect. Nuclear factor kappa B (NFκB) is a regulator of the inflammatory process, and Peroxisome Proliferator-activated… read more here.
Keywords: gamma receptor; gamma; gabapentin; ppar gamma ... See more keywords