Site‐directed mutagenesis improves the practical application of L‐glutamic acid decarboxylase in Escherichia coli
Sign Up to like & getrecommendations! Published in 2023 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202200064
Abstract: γ‐Aminobutyric acid (GABA) is a kind of non‐proteinogenic amino acid which is highly soluble in water and widely used in the food and pharmaceutical industries. Enzymatic conversion is an efficient method to produce GABA, whereby… read more here.
Keywords: practical application; gad; escherichia coli; acid decarboxylase ... See more keywords
GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05130-7
Abstract: Aims/hypothesis Antigen-specific therapy aims to modify inflammatory T cell responses in type 1 diabetes and restore immune tolerance. One strategy employs GAD65 conjugated to aluminium hydroxide (GAD-alum) to take advantage of the T helper (Th)2-biasing… read more here.
Keywords: gad alum; gad specific; gad; type diabetes ... See more keywords
Investigating the association between work family conflict (WFC) and generalized anxiety disorder (GAD) in an Australian community-based cohort study
Sign Up to like & getrecommendations! Published in 2024 at "Social Psychiatry and Psychiatric Epidemiology"
DOI: 10.1007/s00127-024-02672-8
Abstract: Difficulties managing work and family demands are common and have been found to be associated with stress and poor mental health. However, very few studies have examined Work Family Conflict (WFC) in connection with diagnosable… read more here.
Keywords: work family; family; wfc; anxiety ... See more keywords
Effect of generalized anxiety disorders on the success of pessary treatment for pelvic organ prolapse
Sign Up to like & getrecommendations! Published in 2018 at "International Urogynecology Journal"
DOI: 10.1007/s00192-018-3562-1
Abstract: Introduction and hypothesisOur aim was to evaluate the impact of generalized anxiety disorders (GAD) on the effectiveness of pessary treatment for pelvic organ prolapse (POP) in postmenopausal women.MethodsOne-hundred and ten women with symptomatic POP who… read more here.
Keywords: pessary treatment; gad; treatment; generalized anxiety ... See more keywords
A review of neuroimaging studies in generalized anxiety disorder: “So where do we stand?”
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-019-02024-w
Abstract: Generalized anxiety disorder (GAD) is a prevalent anxiety disorder, but is still poorly recognized in clinical practice. The aim of this review is to provide a coherent understanding of the functional neuroanatomy of GAD; second,… read more here.
Keywords: research; anxiety; gad; review ... See more keywords
The Contribution of Worry Behaviors to the Diagnosis of Generalized Anxiety Disorder
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Psychopathology and Behavioral Assessment"
DOI: 10.1007/s10862-018-9683-5
Abstract: Worry behaviors (i.e., overt acts to avoid or cope with worry-induced distress) have been recognized as being important in the psychopathology and treatment of generalized anxiety disorder (GAD). This study evaluated the worry behaviors criterion… read more here.
Keywords: worry; gad; behaviors criterion; worry behaviors ... See more keywords
Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD)
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00486-1
Abstract: This study investigated the effects of vitamin D supplementation on Generalized Anxiety Disorder (GAD) clinical symptoms and neurochemical biomarkers including serotonin, neopterin and kynurenine. Thirty male and female patients diagnosed with GAD and had vitamin… read more here.
Keywords: gad; generalized anxiety; vitamin supplementation; vitamin ... See more keywords
Selection of Escherichia coli Glutamate Decarboxylase Active at Neutral pH from a Focused Library
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-018-0258-9
Abstract: Bacterial glutamate decarboxylase (GAD) converts glutamate (Glu) into γ-aminobutyric acid (GABA) at acidic conditions. Since the reaction consumes a proton per GABA synthesis, cells use this reaction to survive in the acidic environments. Characteristically, the… read more here.
Keywords: escherichia coli; gad; active neutral; glutamate decarboxylase ... See more keywords
Restlessness in Generalized Anxiety Disorder: Using Actigraphy to Measure Physiological Reactions to Threat.
Sign Up to like & getrecommendations! Published in 2021 at "Behavior therapy"
DOI: 10.1016/j.beth.2020.09.004
Abstract: Generalized anxiety disorder (GAD) is characterized by excessive, uncontrollable worry accompanied by symptoms of physiological arousal. Although individuals with GAD report greater subjective arousal than healthy individuals, they show equivalent or even attenuated physiological reactions… read more here.
Keywords: gad; generalized anxiety; anxiety disorder; threat ... See more keywords
Characterization of waste cell biomass derived glutamate decarboxylase for in vitro γ-aminobutyric acid production and value-addition.
Sign Up to like & getrecommendations! Published in 2021 at "Bioresource technology"
DOI: 10.1016/j.biortech.2021.125423
Abstract: Waste biomass of Lactobacillus brevis obtained from in vivo γ-aminobutyric acid (GABA) production was used for value-addition. This study aims to extract glutamate decarboxylase (GAD) and characterize it for in vitro GABA production. Extracted GAD… read more here.
Keywords: production; gad; value addition; acid ... See more keywords
Molecular cloning, expression, and immobilization of glutamate decarboxylase from Lactobacillus fermentum YS2
Sign Up to like & getrecommendations! Published in 2017 at "Electronic Journal of Biotechnology"
DOI: 10.1016/j.ejbt.2017.03.002
Abstract: Background: GABA (γ-aminobutyric acid) is a four-carbon non-protein amino acid and has hypotensive, diuretic, and tranquilizing effects. Glutamate decarboxylase (GAD) is the key enzyme to generate GABA. A simple, economical method of preparing and immobilizing… read more here.
Keywords: fermentum ys2; mso; glutamate decarboxylase; gad ... See more keywords