Effect of simultaneous vaccination with H1N1 and GAD-alum on GAD65-induced immune response
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DOI: 10.1007/s00125-017-4263-x
Abstract: Aims/hypothesisA European Phase III trial of GAD formulated with aluminium hydroxide (GAD-alum) failed to reach its primary endpoint (preservation of stimulated C-peptide secretion from baseline to 15Â months in type 1 diabetes patients), but subgroup analysis… read more here.
Keywords: gad alum; alum; vaccination; gad65 induced ... See more keywords
GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells
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DOI: 10.1007/s00125-020-05130-7
Abstract: Aims/hypothesis Antigen-specific therapy aims to modify inflammatory T cell responses in type 1 diabetes and restore immune tolerance. One strategy employs GAD65 conjugated to aluminium hydroxide (GAD-alum) to take advantage of the T helper (Th)2-biasing… read more here.
Keywords: gad alum; gad specific; gad; type diabetes ... See more keywords
Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes
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DOI: 10.1155/2018/9391845
Abstract: GAD-alum given into lymph nodes to type 1 diabetes patients participating in an open-label pilot trial resulted in preservation of C-peptide similar to promising results from other trials. Here, we compared the immunomodulatory effect of… read more here.
Keywords: gada; administration; gad alum; trial ... See more keywords
Long-Term GAD-alum Treatment Effect on Different T-Cell Subpopulations in Healthy Children Positive for Multiple Beta Cell Autoantibodies
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DOI: 10.1155/2022/3532685
Abstract: Objective The objective of this study was to explore whether recombinant GAD65 conjugated hydroxide (GAD-alum) treatment affected peripheral blood T-cell subpopulations in healthy children with multiple beta cell autoantibodies. Method The Diabetes Prevention–Immune Tolerance 2… read more here.
Keywords: cell; cell subpopulations; gad alum; alum treatment ... See more keywords
Intralymphatic GAD-alum Injection Modulates B Cell Response and Induces Follicular Helper T Cells and PD-1+ CD8+ T Cells in Patients With Recent-Onset Type 1 Diabetes
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DOI: 10.3389/fimmu.2021.797172
Abstract: Antigen-specific immunotherapy is an appealing strategy to preserve beta-cell function in type 1 diabetes, although the approach has yet to meet its therapeutic endpoint. Direct administration of autoantigen into lymph nodes has emerged as an… read more here.
Keywords: follicular helper; gad alum; type diabetes; cd8 cells ... See more keywords