UVB-induced eIF2α phosphorylation in keratinocytes depend on decreased ATF4, GADD34 and CReP expression levels.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120044
Abstract: AIM To elucidate the mechanism behind the sustained high levels of phosphorylated eIF2α in HaCaT cells post-UVB. MAIN METHODS In this study, expression levels of the machinery involved in the dephosphorylation of eIF2α (GADD34, CReP… read more here.
Keywords: gadd34; expression; atf4 gadd34; phosphorylation ... See more keywords
Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01388-21
Abstract: Identification of host factors involved in viral replication is an important approach in discovering viral pathogenic mechanisms and identifying potential therapeutic targets. Previously, we screened host proteins that were upregulated by EV71 infection. ABSTRACT Enterovirus… read more here.
Keywords: replication; host protein; gadd34; precursor ... See more keywords
Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma
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DOI: 10.1158/1078-0432.ccr-17-2954
Abstract: Purpose: Glioblastoma (GBM) is the most common primary central nervous system cancer in adults. Oncolytic HSV-1 (oHSV) is the first FDA-approved gene therapy approach for the treatment of malignant melanoma. For GBM, oHSVs need to… read more here.
Keywords: glioblastoma; oncolytic hsv; gbm; treatment ... See more keywords
GADD34 activates p53 and may have utility as a marker of atherosclerosis
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DOI: 10.3389/fmed.2023.1128921
Abstract: We previously identified growth arrest and DNA-damage-inducible gene 34 (GADD34) as a marker of ischemic stroke. In the present study, serum levels of anti-GADD34 antibodies were found to be significantly higher in patients with acute… read more here.
Keywords: marker; gadd34; p53; gadd34 activates ... See more keywords