LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "gadd45" as a keyword



GADD45: a crucial component of the dna damage response and a potential cancer therapeutic target.

Sign Up to like & get
recommendations! Published in 2025 at "Expert opinion on therapeutic targets"

DOI: 10.1080/14728222.2025.2589807

Abstract: ABSTRACT Introduction The Growth Arrest and DNA Damage-Inducible 45 (GADD45) proteins, including GADD45α, GADD45β, and GADD45γ, play a crucial role in the cellular stress response and maintaining genome stability. These proteins are involved in various… read more here.

Keywords: gadd45; cancer; damage; stress ... See more keywords

Ablation of Gadd45β ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction

Sign Up to like & get
recommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.15519

Abstract: The growth arrest and DNA damage‐inducible beta (Gadd45β) protein have been associated with various cellular functions, but its role in progressive renal disease is currently unknown. Here, we examined the effect of Gadd45β deletion on… read more here.

Keywords: ureteral obstruction; unilateral ureteral; gadd45; inflammation renal ... See more keywords

GADD45β Loss Ablates Innate Immunosuppression in Cancer.

Sign Up to like & get
recommendations! Published in 2018 at "Cancer research"

DOI: 10.1158/0008-5472.can-17-1833

Abstract: T-cell exclusion from the tumor microenvironment (TME) is a major barrier to overcoming immune escape. Here, we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumor-associated inflammation and T-cell trafficking… read more here.

Keywords: loss ablates; gadd45; gadd45 loss; ablates innate ... See more keywords

Deficiency of GADD45α-R-Loop Pathway and Kidney Injury in Diabetic Nephropathy.

Sign Up to like & get
recommendations! Published in 2025 at "Journal of the American Society of Nephrology : JASN"

DOI: 10.1681/asn.0000000681

Abstract: BACKGROUND Diabetic nephropathy is a primary cause of kidney failure. Persistent hyperglycemia causes metabolic perturbations epigenetically dysregulating gene expression in renal cells, thereby leading to diabetic nephropathy pathogenesis. On analyzing the GEO database by using… read more here.

Keywords: gadd45 loop; gadd45; loop pathway; diabetic nephropathy ... See more keywords

GADD45β Regulates Hepatic Gluconeogenesis via Modulating the Protein Stability of FoxO1

Sign Up to like & get
recommendations! Published in 2021 at "Biomedicines"

DOI: 10.3390/biomedicines9010050

Abstract: Increased hepatic gluconeogenesis is one of the main contributors to the development of type 2 diabetes. Recently, it has been reported that growth arrest and DNA damage-inducible 45 beta (GADD45β) is induced under both fasting… read more here.

Keywords: gadd45; stability foxo1; hepatic gluconeogenesis; protein stability ... See more keywords