Ablation of Gadd45β ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15519
Abstract: The growth arrest and DNA damage‐inducible beta (Gadd45β) protein have been associated with various cellular functions, but its role in progressive renal disease is currently unknown. Here, we examined the effect of Gadd45β deletion on… read more here.
Keywords: ureteral obstruction; unilateral ureteral; gadd45; inflammation renal ... See more keywords
GADD45β Loss Ablates Innate Immunosuppression in Cancer.
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DOI: 10.1158/0008-5472.can-17-1833
Abstract: T-cell exclusion from the tumor microenvironment (TME) is a major barrier to overcoming immune escape. Here, we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumor-associated inflammation and T-cell trafficking… read more here.
Keywords: loss ablates; gadd45; gadd45 loss; ablates innate ... See more keywords
GADD45β Regulates Hepatic Gluconeogenesis via Modulating the Protein Stability of FoxO1
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DOI: 10.3390/biomedicines9010050
Abstract: Increased hepatic gluconeogenesis is one of the main contributors to the development of type 2 diabetes. Recently, it has been reported that growth arrest and DNA damage-inducible 45 beta (GADD45β) is induced under both fasting… read more here.
Keywords: gadd45; stability foxo1; hepatic gluconeogenesis; protein stability ... See more keywords