Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxab001
Abstract: Increased neurogenesis elicits antidepressive-like effects. The antidiabetic drug metformin (Met) reportedly promotes hippocampal neurogenesis, which ameliorates spatial memory deficits and depression-like behaviors. However, the precise molecular mechanisms underpinning Met-induced neuronal differentiation of neural stem cells… read more here.
Keywords: induced neuronal; gadd45g; demethylation; neuronal differentiation ... See more keywords
Effect of GADD45G on the radioresistance of nasopharyngeal carcinoma cells.
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DOI: 10.1097/cad.0000000000001145
Abstract: The development of radioresistance by nasopharyngeal carcinoma (NPC) cells almost always results in tumor recurrence and metastasis, making clinical treatment of the disease difficult. In this study, the mechanism of radioresistance in NPC cells was… read more here.
Keywords: radioresistance; radioresistance nasopharyngeal; npc cells; cell ... See more keywords
Gadd45g is required for timely Sry expression independently of RSPO1 activity.
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DOI: 10.1530/rep-21-0443
Abstract: Sex determination in mammals is controlled by the dominance of either pro-testis (SRY-SOX9-FGF9) or pro-ovary (RSPO1-WNT4-FOXL2) genetic pathways during early gonad development in XY and XX embryos, respectively. We have previously shown that early, robust… read more here.
Keywords: expression; sry expression; sex reversal; gadd45g ... See more keywords
Expression of GADD45G and CAPRIN1 in Human Nucleus Pulposus: Implications for Intervertebral Disc Degeneration
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DOI: 10.3390/ijms24065768
Abstract: Marked cellular changes occur in human intervertebral disc (IVD) degeneration during disc degeneration with biochemical changes. Genome-wide analysis of the DNA methylation profile has identified 220 differentially methylated loci associated with human IVD degeneration. Among… read more here.
Keywords: expression gadd45g; gadd45g caprin1; degeneration; gadd45g ... See more keywords