Contrast‐enhanced CT imaging as a non‐destructive tool for ex vivo examination of the biochemical content and structure of the human meniscus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23337
Abstract: The biochemical and histopathological techniques used to investigate meniscal content and structure are destructive and time‐consuming. Therefore, this study evaluated whether contrast‐enhanced computed tomography (CECT) attenuation and contrast agent flux using the iodinated contrast agents… read more here.
Keywords: contrast; gag; content; water content ... See more keywords
Membrane defects and genetic redundancy: Are we at a turning point for DYT1 dystonia?
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26880
Abstract: Heterozygosity for a 3‐base pair deletion (ΔGAG) in TOR1A/torsinA is one of the most common causes of hereditary dystonia. In this review, we highlight current understanding of how this mutation causes disease from research spanning… read more here.
Keywords: gag; defects genetic; dystonia; genetic redundancy ... See more keywords
Imaging Glycosaminoglycan Modification Patterns In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1398-6_42
Abstract: Glycosaminoglycans (GAGs) such as heparan sulfates (HS) or chondroitin sulfates (CS) are long unbranched polymers of a disaccharide comprised of hexuronic acid and hexosamine. Attached to a protein backbone via a characteristic tetrasaccharide, the GAG… read more here.
Keywords: patterns vivo; modification patterns; gag; glycosaminoglycan modification ... See more keywords
Induction of a high-titered antibody response using HIV gag-EV71 VP1-based virus-like particles with the capacity to protect newborn mice challenged with a lethal dose of enterovirus 71
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3797-7
Abstract: Enterovirus 71 (EV71) is the most frequently detected causative agent in hand, foot, and mouth disease (HFMD) and is a serious threat to public health in the Asia-Pacific region. Many EV71 vaccines are under development worldwide,… read more here.
Keywords: ev71 vp1; virus like; gag; vp1 ... See more keywords
Genomic RNA Binding Promotes Retroviral Gag Protein Interactions in an Assembly-Competent Conformation Leading to Selective Genome Packaging
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1699
Abstract: In HIV-1 infected cells, full-length viral genomic RNA (gRNA) is selectively packaged by the HIV-1 Gag protein despite a vast excess of spliced viral and host RNAs. The mechanism of this selective packaging is incompletely… read more here.
Keywords: psi rna; gag; rna; genomic rna ... See more keywords
Binding Kinetics and Lateral Mobility of HSV-1 on End-Grafted Sulfated Glycosaminoglycans.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.06.028
Abstract: Many viruses, including herpes simplex (HSV), are recruited to their host cells via interaction between their envelope glycoproteins and cell-surface glycosaminoglycans (GAGs). This initial attachment is of a multivalent nature, i.e., it requires the establishment… read more here.
Keywords: lateral mobility; mobility; gag; binding kinetics ... See more keywords
The road to animal-free glycosaminoglycan production: current efforts and bottlenecks.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2017.12.018
Abstract: Animal-extraction, despite its limitations, continues to monopolize the fast-growing glycosaminoglycan (GAG) industry. The past few years have seen an increased interest in the development of alternative GAG production methods. Chemical and chemo-enzymatic synthesis and biosynthesis… read more here.
Keywords: production; gag; road animal; biology ... See more keywords
A Phase I clinical trial of the knee to assess the correlation of gagCEST MRI, delayed gadolinium-enhanced MRI of cartilage and T2 mapping.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2017.02.030
Abstract: PURPOSE Osteoarthritis (OA) is associated with the loss of glycosaminoglycan (GAG) during disease progression, which can be detected by glycosaminoglycan chemical exchange-dependent saturation transfer (gagCEST) MRI. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is considered one… read more here.
Keywords: gagcest mri; gag; correlation gagcest; mri ... See more keywords
Preparation of divalent antigen-displaying enveloped virus-like particles using a single recombinant Bombyx mori nucleopolyhedrovirus bacmid in silkworms.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2020.08.002
Abstract: Silkworms have been used as a host for the production of recombinant proteins in a baculovirus expression system using Bombyx mori nucleopolyhedrovirus (BmNPV). To coexpress several recombinant proteins, a silkworm must be coinfected with several… read more here.
Keywords: bombyx mori; mori nucleopolyhedrovirus; virus like; gag ... See more keywords
Synthetic Xylosides: Probing the Glycosaminoglycan Biosynthetic Machinery for Biomedical Applications.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.7b00289
Abstract: Glycosaminoglycans (GAGs) are polysaccharides ubiquitously found on cell surfaces and in the extracellular matrix (ECM). They regulate numerous cellular signaling events involved in many developmental and pathophysiological processes. GAGs are composed of complex sequences of… read more here.
Keywords: gag; biosynthetic machinery; synthetic xylosides; cell ... See more keywords
Porphyrin-GO nanocomposites based NIR fluorescent sensor array for heparin sensing and quality control.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c00808
Abstract: Heparin (Hep), widely used in clinics as an anticoagulant drug, has high degrees of heterogeneity and shares a similar disaccharide repeating unit with its GAG analogues. The development of reliable and convenient methods to discriminate… read more here.
Keywords: heparin; gag; sensor array; porphyrin nanocomposites ... See more keywords