Murine Fibroblasts and Primary Hepatocytes as Tools When Studying the Efficacy of Potential Therapies for Mucopolysaccharidosis Type I
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DOI: 10.3390/ijms24010534
Abstract: Mucopolysaccharidosis type I (MPS I) is a metabolic genetic disease caused by the deficiency of a lysosomal enzyme involved in glycosaminoglycans (GAGs) degradation. MPS I cells have a constant level of GAG synthesis, but disturbed… read more here.
Keywords: mucopolysaccharidosis type; primary hepatocytes; potential therapies; synthesis ... See more keywords
Restoration of the Phenotype of Dedifferentiated Rabbit Chondrocytes by Sesquiterpene Farnesol
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DOI: 10.3390/pharmaceutics14010186
Abstract: Osteoarthritis (OA) is a joint disorder characterized by the progressive degeneration of articular cartilage. The phenotype and metabolism behavior of chondrocytes plays crucial roles in maintaining articular cartilage function. Chondrocytes dedifferentiate and lose their cartilage… read more here.
Keywords: col; gag synthesis; farnesol; phenotype ... See more keywords