No pains, no gains: how chromosome fragmentation promotes gene amplification.
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DOI: 10.1016/j.molcel.2021.02.018
Abstract: Combining live-cell imaging, cytogenetics, genome sequencing, and in vitro evolution, Shoshani et al. (2020) revealed deep connections between chromothripsis, the catastrophic shattering of a chromosome in abnormal nuclear structures, and gene amplification, a frequent culprit of oncogenic… read more here.
Keywords: chromosome fragmentation; gains chromosome; pains gains; gene ... See more keywords