Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
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DOI: 10.1021/acs.jmedchem.8b00613
Abstract: There is an urgent need for strategies to combat dengue and other emerging viral infections. We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin-associated host adaptor proteins AP-1 and AP-2, regulates… read more here.
Keywords: associated kinase; gak; kinase gak; cyclin associated ... See more keywords
Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase
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DOI: 10.26508/lsa.201800118
Abstract: Novel GAK phosphorylation targets are identified using chemical genetic methods. One of the substrates is the α subunit of the Na+/K+-ATPase, phosphorylation of which is necessary for its surface trafficking from endosomes. Conserved functions of… read more here.
Keywords: chemical genetic; gak; identification gak; role ... See more keywords