Galectin‐3 contributes to vascular fibrosis in monocrotaline‐induced pulmonary arterial hypertension rat model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21879
Abstract: Galectin‐3 (Gal‐3) plays a critical role in vascular inflammation and fibrosis. The role of TGF‐β1 in mediating pulmonary vascular fibrosis is well documented; thus, we suspected that Gal‐3 could be an important factor in TGF‐β1‐induced… read more here.
Keywords: fibrosis; galectin contributes; gal; vascular fibrosis ... See more keywords
Reply to: The antibody response to the glycan α‐Gal correlates with COVID‐19 symptoms
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27022
Abstract: We read with interest two recent papers which discussed possible connections between the immune response to galactose-⍺-1,3-galactose (⍺-Gal) and COVID-19(1, 2). This article is protected by copyright. All rights reserved. read more here.
Keywords: glycan gal; response; gal; reply antibody ... See more keywords
Silencing of galectin‐1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen‐induced ischemic retinopathy
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.02.015
Abstract: Abstract Aberrant neovascularization is a consequence of inappropriate angiogenic signaling and contributes to several diseases. Although many regulators of pathogenic angiogenesis have been identified, the understanding of this process remains incomplete. Galectin‐1 (Gal‐1), as a… read more here.
Keywords: retinal hypoxia; gal; model; neovascularization ... See more keywords
Characterization and comparison of the structure and antioxidant activity of glycosylated whey peptides from two pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Food chemistry"
DOI: 10.1016/j.foodchem.2018.02.155
Abstract: Glycosylated whey peptides (WPP-Gal A and WPP-Gal B) were formed from two pathways. WPP-Gal A showed higher browning intensity and fluorescence intensity than WPP-Gal B. Loss of amino groups and reducing sugar was heavier for… read more here.
Keywords: antioxidant activity; gal; wpp gal; glycosylated whey ... See more keywords
In-situ SERS readout strategy to improve the reliability of beta-galactosidase activity assay based on X-gal staining in shortening incubation times.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2021.122689
Abstract: Beta-galactosidase (β-gal) activity is closed related with senescence cells and aging-associated diseases, however, the traditional readout of β-gal activity based on X-gal staining was limited to low sensitivity in short incubation times and false positives… read more here.
Keywords: gal; readout strategy; gal staining; sers readout ... See more keywords
An Activatable NIR Probe for the Detection and Elimination of Senescent Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00239
Abstract: Cellular senescence is involved in diverse physiological processes. Accumulation of senescent cells can lead to numerous age-related diseases. Therefore, it is of great significance to develop chemical tools to effectively detect and eliminate senescent cells.… read more here.
Keywords: eliminate senescent; gal; detect eliminate; senescent ... See more keywords
Glycopolymers Decorated with 3-O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin-3.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01625
Abstract: Galectin-3 (Gal-3) participates in many cancer-related metabolic processes. The inhibition of overexpressed Gal-3 by, e.g., β-galactoside-derived inhibitors is hence promising for cancer treatment. The multivalent presentation of such inhibitors on a suitable biocompatible carrier can… read more here.
Keywords: gal; substituted thiodigalactosides; glycopolymers decorated; decorated substituted ... See more keywords
Galectin-3 promotes Aβ oligomerization and Aβ toxicity in a mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-019-0348-z
Abstract: Amyloid-β (Aβ) oligomers largely initiate the cascade underlying the pathology of Alzheimer’s disease (AD). Galectin-3 (Gal-3), which is a member of the galectin protein family, promotes inflammatory responses and enhances the homotypic aggregation of cancer… read more here.
Keywords: gal; ps1 mice; expression; mice ... See more keywords
Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20171389
Abstract: Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. We investigated whether Gal-3 modulates oxidative stress in human cardiac fibroblasts, in experimental animal models and in human aortic stenosis (AS).… read more here.
Keywords: gal; prx; cardiac fibroblasts; human cardiac ... See more keywords
Galectin-3 is inversely associated with cardiorespiratory fitness in the general population
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Preventive Cardiology"
DOI: 10.1093/eurjpc/zwab061.208
Abstract: Type of funding sources: None. Low cardiorespiratory fitness (CRF) is associated with high mortality and morbidity. Galectin-3 (Gal-3) is a prognostic biomarker for fibrosis, different cancers, renal impairment and, in particular, for heart failure. Further,… read more here.
Keywords: cardiorespiratory fitness; gal; galectin; general population ... See more keywords
Identification of key amino acid residues determining ligand binding specificity, homodimerization and cellular distribution of human galectin-10
Sign Up to like & getrecommendations! Published in 2019 at "Glycobiology"
DOI: 10.1093/glycob/cwy087
Abstract: Charcot-Leyden crystal protein/Gal-10, abundantly expressed in eosinophils and basophils, is related to several immune diseases. Recently, crystallographic and biochemical studies showed that Gal-10 cannot bind lactose, because a glutamate residue (Glu33) from another monomer blocks… read more here.
Keywords: gal; ligand binding; identification key; distribution ... See more keywords