Paleo‐immunology of human anti‐carbohydrate antibodies preventing primate extinctions
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DOI: 10.1111/imm.13582
Abstract: Two human natural anti‐carbohydrate antibodies appeared in critical evolutionary events that brought primates and hominins to brink of extinction. The first is the anti‐Gal antibody, produced in Old‐World monkeys (OWM), apes and humans. It binds… read more here.
Keywords: gal epitopes; carbohydrate antibodies; anti; anti carbohydrate ... See more keywords
No clinically relevant hypersensitivity reactions in clinical trials with tralokinumab in asthma
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DOI: 10.1183/13993003.congress-2018.pa1034
Abstract: Introduction: Anaphylaxis and severe hypersensitivity reactions are a concern for any biologic substance. The anti-IL-13 agent tralokinumab is produced by a murine cell line and may thus incorporate immunogenic α-Gal epitopes in the Fab domain.… read more here.
Keywords: clinical studies; severe hypersensitivity; gal epitopes; hypersensitivity reactions ... See more keywords
A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express α-gal epitopes
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DOI: 10.1371/journal.pone.0184901
Abstract: Objectives Single-agent immunotherapy is ineffective against poorly immunogenic cancers, including pancreatic ductal adenocarcinoma (PDAC). The aims of this study were to demonstrate the feasibility of production of novel autologous tumor lysate vaccines from resected PDAC… read more here.
Keywords: tumor lysate; gal epitopes; pancreatic cancer; lysate vaccines ... See more keywords