Pterostilbene Exerts Hepatoprotective Effects through Ameliorating LPS/D-Gal-Induced Acute Liver Injury in Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01349-z
Abstract: Acute liver injury (ALI) refers to abnormalities in liver function caused by various causes and accompanied by poor prognosis and high mortality. Common predisposing factors for the disease are viral hepatitis, bacteria, alcohol, and certain… read more here.
Keywords: acute liver; gal induced; lps gal; liver injury ... See more keywords
Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.146834
Abstract: To investigate the effect of electroacupuncture (EA) on cognitive function and insulin resistance (IR) in an Al/D-gal-induced aging model for Alzheimer's disease (AD) using Ostuka Long-Evans Tokushima Fatty (OLETF) rats. The Al/D-gal-OLETF rats for AD… read more here.
Keywords: gal induced; signaling pathway; model; insulin resistance ... See more keywords
Preventive effects of interleukin‐6 in lipopolysaccharide/d‐galactosamine induced acute liver injury via regulating inflammatory response in hepatic macrophages
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.08.009
Abstract: Abstract Lipopolysaccharide/d‐Galactosamine (LPS/d‐Gal)‐induced acute liver injury is characterized by significant inflammatory responses including TNF‐&agr; and interleukin‐6 (IL‐6) and is a widely applied experimental model for inflammation research. TNF‐&agr; is critical in the progression of LPS/d‐Gal‐induced… read more here.
Keywords: acute liver; gal induced; lps gal; liver injury ... See more keywords
Shikonin ameliorates D-galactose-induced oxidative stress and cognitive impairment in mice via the MAPK and nuclear factor-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106491
Abstract: Oxidative stress acts as the major causative factor for various age-associated neurodegenerative diseases, triggering cognitive and memory impairments. In the present study, the underlying neuroprotective mechanism governing how shikonin acts against D-galactose (D-gal)-induced memory impairment,… read more here.
Keywords: gal induced; impairment; factor; nuclear factor ... See more keywords
Protective Effect of 20(S)-Protopanaxadiol on D-Gal-Induced Cognitively Impaired Mice Based on Its Target Protein Brain-type Creatine Kinase.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07889
Abstract: Ginseng is an important medicinal herb consumed as dietary supplements. Ginsenosides and their metabolites have been reported to enhance cognitive performance, but their underlying mechanisms remain unclear. Brain-type creatine kinase (CK-BB) was previously screened out… read more here.
Keywords: type creatine; gal induced; ppd; brain type ... See more keywords
The Anti-inflammatory Effects of Isoflavonoids from Radix Astragali in Hepatoprotective Potential against LPS/D-gal-induced Acute Liver Injury
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DOI: 10.1055/a-1953-0369
Abstract: Abstract Radix Astragali (RA) is an important Traditional Chinese Medicine widely used in the treatment of various diseases, such as pneumonia, atherosclerosis, diabetes, kidney and liver fibrosis. The role of isoflavonoids from RA in the… read more here.
Keywords: gal induced; liver injury; anti inflammatory; effects isoflavonoids ... See more keywords
Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Rejuvenation research"
DOI: 10.1089/rej.2017.1919
Abstract: Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior… read more here.
Keywords: baicalein; dysfunction; gal induced; attenuation inflammation ... See more keywords
Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in d-galactose-induced aging rats
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DOI: 10.2147/cia.s132277
Abstract: Background Recently, the d-galactose (d-gal)-induced mimetic aging rat model has been widely used in studies of age-associated diseases, which have shown that chronic d-gal exposure induces premature aging similar to natural aging in rats. With… read more here.
Keywords: sepsis; inflammatory response; gal induced; model ... See more keywords
Osthole Alleviates D-Galactose-Induced Liver Injury In Vivo via the TLR4/MAPK/NF-κB Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28010443
Abstract: Osthole, a coumarin derivative, is found in several medicinal herbs. However, the protective effects of osthole against D-galactose (D-Gal)-induced liver injury still remain unclear. In this study, osthole treatment effectively reversed D-Gal-induced liver injury, according… read more here.
Keywords: liver injury; via tlr4; gal induced; induced liver ... See more keywords