An approach to a patient with suspected meat allergy due to underlying alpha-Gal syndrome in a resource-limited setting
Sign Up to like & getrecommendations! Published in 2022 at "JAAD Case Reports"
DOI: 10.1016/j.jdcr.2022.01.025
Abstract: IgE: immunoglobulin E INTRODUCTION The alpha-Gal syndrome is a type of food allergy in which antibodies against the galactose a-1, 3-galactose are generated. Patients with alpha-Gal syndrome typically present with symptoms related to allergic reactions,… read more here.
Keywords: gal syndrome; alpha gal; meat; allergy ... See more keywords
Fatal anaphylaxis due to alpha-gal syndrome after initial cetuximab administration: The first forensic case report.
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DOI: 10.1016/j.legalmed.2021.101878
Abstract: Cetuximab is mainly used for the treatment of advanced and metastatic colorectal cancer. Owing to the oligosaccharide galactose-α-1,3-galactose (α-gal) in its heavy chain, cetuximab can induce severe IgE-dependent anaphylaxis. α-Gal is also the antigen responsible… read more here.
Keywords: medicine; administration; cetuximab; gal syndrome ... See more keywords
Delayed hypersensitivity reaction to mammalian galactose-α-1,3-galactose (α-Gal) after repeated tick bites in a patient from France.
Sign Up to like & getrecommendations! Published in 2019 at "Ticks and tick-borne diseases"
DOI: 10.1016/j.ttbdis.2019.05.017
Abstract: The α-Gal syndrome is a tick-associated and emerging IgE-mediated hypersensitivity reaction directed against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) epitope after red meat intake. Herein, we describe a clinical case of a 44-year-old French patient who suffered… read more here.
Keywords: delayed hypersensitivity; hypersensitivity reaction; tick bites; gal syndrome ... See more keywords
Tick exposures and alpha-gal syndrome: A systematic review of the evidence.
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DOI: 10.1016/j.ttbdis.2021.101674
Abstract: Alpha-gal syndrome (AGS) refers to a delayed allergic reaction to galactose-α-1,3-galactose (α-Gal) that occurs following the consumption of mammalian meat or exposure to other animal-based foods and products. Increasing evidence suggests that bites from certain… read more here.
Keywords: tick; systematic review; tick exposures; gal syndrome ... See more keywords
Alpha-Gal Syndrome in the Infectious Diseases Clinic: A Series of 5 Cases in Central North Carolina
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DOI: 10.1093/ofid/ofac663
Abstract: Abstract Background Alpha-gal syndrome (AGS) is a recently described allergy to galactose-α-1,3-galactose, an oligosaccharide present in mammalian meat. AGS can present with angioedema, urticaria, and anaphylaxis arising 3–6 hours after ingestion, although symptoms such as gastrointestinal… read more here.
Keywords: infectious diseases; gal syndrome; series; alpha gal ... See more keywords
Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma and Allergy"
DOI: 10.2147/jaa.s265660
Abstract: Abstract The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed anaphylaxis in foods containing the oligosaccharide galactose-α-1,3-galactose (α-Gal) such as mammalian meat or dairy products. Clinical presentation of AGS can also comprise immediate… read more here.
Keywords: gal syndrome; diagnosis treatment; treatment; syndrome ags ... See more keywords
Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack
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DOI: 10.3389/fcimb.2021.680264
Abstract: Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the vertebrate host. Alpha-gal syndrome (AGS), a newly reported food allergy, is… read more here.
Keywords: tick saliva; tick; alpha gal; gal syndrome ... See more keywords
T and B Lymphocyte Transcriptional States Differentiate between Sensitized and Unsensitized Individuals in Alpha-Gal Syndrome
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DOI: 10.3390/ijms22063185
Abstract: The mechanisms of pathogenesis driving alpha-gal syndrome (AGS) are not fully understood. Differences in immune gene expression between AGS individuals and non-allergic controls may illuminate molecular pathways and targets critical for AGS development. We performed… read more here.
Keywords: gene expression; gal syndrome; expression; lymphocyte transcriptional ... See more keywords