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   Articles with "gal4" as a keyword



Development of a temperature‐responsive yeast cell factory using engineered Gal4 as a protein switch

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recommendations! Published in 2018 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.26544

Abstract: Conflict between cell growth and product accumulation is frequently encountered in biosynthesis of secondary metabolites. Herein, a temperature‐dependent dynamic control strategy was developed by modifying the GAL regulation system to facilitate two‐stage fermentation in yeast.… read more here.

Keywords: gal4; temperature; temperature responsive; yeast ... See more keywords

Refinement of ectopic protein expression through the GAL4/UAS system in Bombyx mori: application to behavioral and developmental studies

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-12102-2

Abstract: Silkmoth, Bombyx mori, is one of the important model insects in which transgenic techniques and the GAL4/UAS system are applicable. However, due to cytotoxicity and low transactivation activity of GAL4, effectiveness of the GAL4/UAS system… read more here.

Keywords: gal4; system; bombyx mori; gal4 uas ... See more keywords
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Proteomic mapping of Drosophila transgenic elav.L-GAL4/+ brain as a tool to illuminate neuropathology mechanisms

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-62510-0

Abstract: Drosophila brain has emerged as a powerful model system for the investigation of genes being related to neurological pathologies. To map the proteomic landscape of fly brain, in a high-resolution scale, we herein employed a… read more here.

Keywords: drosophila; gal4; mapping drosophila; elav ... See more keywords

Drosophila Hox genes induce melanized pseudo-tumors when misexpressed in hemocytes

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-81472-5

Abstract: Hox genes are early determinants of cell identity along the anterior–posterior body axis across bilaterians. Several late non-homeotic functions of Hox genes have emerged in a variety of processes involved in organogenesis in several organisms,… read more here.

Keywords: gal4; hox genes; group; pseudo tumors ... See more keywords

A drug stabilizable GAL80ds for conditional control of gene expression via GAL4-UAS and CRISPR-Cas9 systems in Drosophila

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-56343-4

Abstract: The binary GAL4-UAS expression system has been widely used in Drosophila to achieve tissue-specific expression of genes. To further allow for simultaneous spatial and conditional control of gene expression in existing GAL4 expression lines backgrounds,… read more here.

Keywords: gal4; conditional control; drug; expression ... See more keywords
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Characterizing a gene expression toolkit for eye- and photoreceptor-specific expression in Drosophila

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recommendations! Published in 2021 at "Fly"

DOI: 10.1080/19336934.2021.1915683

Abstract: ABSTRACT Binary expression systems are a powerful tool for tissue- and cell-specific research. Many of the currently available Drosophila eye-specific drivers have not been systematically characterized for their expression level and cell-type specificity in the… read more here.

Keywords: gal4; microscopy; gene expression; toolkit eye ... See more keywords

Stage-specific modulation of Drosophila gene expression with muscle GAL4 promoters

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recommendations! Published in 2025 at "Fly"

DOI: 10.1080/19336934.2024.2447617

Abstract: ABSTRACT The bipartite GAL4/UAS system is the most widely used method for targeted gene expression in Drosophila melanogaster and facilitates rapid in vivo genetic experimentation. Defining precise gene expression patterns for tissues and/or cell types… read more here.

Keywords: gene expression; muscle; gal4; expression ... See more keywords

Using tissue specific P450 expression in Drosophila melanogaster larvae to understand the spatial distribution of pesticide metabolism in feeding assays

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recommendations! Published in 2022 at "Insect Molecular Biology"

DOI: 10.1111/imb.12765

Abstract: Drug metabolizing enzymes such as cytochrome P450s have often been implicated in influencing levels of pesticide toxicology and resistance. Consequently, a variety of different P450 genes and variants have been linked to pesticide metabolism. Substantially… read more here.

Keywords: pesticide metabolism; toxicology; p450; gal4 ... See more keywords

Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0196365

Abstract: The ability to express a gene of interest in a spatio-temporal manner using Gal4-UAS system has allowed the use of Drosophila model to study various biological phenomenon. During Drosophila eye development, a synchronous wave of… read more here.

Keywords: gal4; gal4 driver; dpp; gene ... See more keywords

Modeling transcriptional activation changes to Gal4 variants via structure-based computational mutagenesis

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recommendations! Published in 2018 at "PeerJ"

DOI: 10.7717/peerj.4844

Abstract: As a DNA binding transcriptional activator, Gal4 promotes the expression of genes responsible for galactose metabolism. The Gal4 protein from Saccharomyces cerevisiae (baker’s yeast) has become a model for studying eukaryotic transcriptional activation in general… read more here.

Keywords: gal4; mutagenesis; gal4 variants; structure ... See more keywords