Molecular Dynamics Simulations of Substrate Release from Trypanosoma cruzi UDP-Galactopyranose Mutase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00675
Abstract: The enzyme UDP-galactopyranose mutase (UGM) represents a promising drug target for the treatment of infections with Trypanosoma cruzi. We have computed the Potential of Mean Force for the release of UDP-galactopyranose from UGM, using Umbrella… read more here.
Keywords: release; galactopyranose mutase; trypanosoma cruzi; udp galactopyranose ... See more keywords
Deleterious Consequences of UDP-Galactopyranose Mutase Inhibition for Nematodes.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00487
Abstract: Parasitic nematodes pose a serious threat to agriculture, livestock, and human health. Increasing resistance to antiparasitic agents underscores the need to replenish our anthelmintic arsenal. The nonpathogenic Caenorhabditis elegans, which serves as an effective model… read more here.
Keywords: ugm inhibitors; udp galactopyranose; deleterious consequences; consequences udp ... See more keywords