Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments
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DOI: 10.1016/j.neuroscience.2017.04.050
Abstract: Chitinase activity is increased in Alzheimer's disease (AD). However, the role of chitinase1 in AD is unknown. We investigated the effects of chitinase1 on Alzheimer's pathology and microglia function. Artificial chitinase1 and chitinase inhibitor (chitinase-IN-2)… read more here.
Keywords: model cognitive; cognitive impairments; induced rat; galactose alcl3 ... See more keywords
Ameliorative effects and possible molecular mechanisms of action of fibrauretine from Fibraurea recisa Pierre on D-galactose/AlCl3-mediated Alzheimer's disease
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DOI: 10.1039/c8ra05356a
Abstract: Fibrauretine is one of the main active ingredients from the rattan stems of Fibraurea recisa Pierre It exhibits a series of significant pharmacological effects. The present study aimed to evaluate the potential anti Alzheimer's disease… read more here.
Keywords: alzheimer disease; mechanisms action; galactose alcl3; alcl3 ... See more keywords