Patients with IgG1-anti-red blood cell autoantibodies show aberrant Fc-glycosylation
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08654-y
Abstract: Autoimmune hemolytic anemia (AIHA) is a potentially severe disease in which red blood cells (RBC) are destroyed by IgG anti-RBC autoantibodies which can lead to hemolysis. We recently found IgG Fc-glycosylation towards platelet and RBC… read more here.
Keywords: red blood; galactosylation; glycosylation; sialylation ... See more keywords
Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation
Sign Up to like & getrecommendations! Published in 2021 at "mAbs"
DOI: 10.1080/19420862.2021.1893427
Abstract: ABSTRACT Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation between galactosylation and CDC has… read more here.
Keywords: galactosylation; hexamerization; complement activation; reaction ... See more keywords
Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2145929
Abstract: ABSTRACT A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, which are considered a… read more here.
Keywords: clearance; injection; galactosylation; intravenous injection ... See more keywords
BGAL1 depletion boosts the level of β‐galactosylation of N‐ and O‐glycans in N. benthamiana
Sign Up to like & getrecommendations! Published in 2019 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13316
Abstract: Summary Glyco‐design of proteins is a powerful tool in fundamental studies of structure–function relationship and in obtaining profiles optimized for efficacy of therapeutic glycoproteins. Plants, particularly Nicotiana benthamiana, are attractive hosts to produce recombinant glycoproteins,… read more here.
Keywords: plant; depletion boosts; galactosylation; galactose residues ... See more keywords
mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1020844
Abstract: Background The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS-CoV-2 and code for its spike (S) protein. Several studies have investigated short-term antibody (Ab)… read more here.
Keywords: long term; adenovirus based; sialylation; galactosylation ... See more keywords
Specific location of galactosylation in an afucosylated antiviral monoclonal antibody affects its FcγRIIIA binding affinity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.972168
Abstract: Monoclonal antibodies (mAbs) comprise an essential type of biologic therapeutics and are used to treat diseases because of their anti-cancer and anti-inflammatory properties, and their ability to protect against respiratory infections. Its production involves post-translational… read more here.
Keywords: riiia binding; binding affinity; specific location; galactosylation ... See more keywords
The B-Cell-Specific Ablation of B4GALT1 Reduces Cancer Formation and Reverses the Changes in Serum IgG Glycans during the Induction of Mouse Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14051333
Abstract: Simple Summary As serum IgG glycosylation is associated with various cancers, our goal is to explore whether serum IgG galactosylation and its associated glycans could be used as tumor markers associated with hepatocellular carcinoma (HCC).… read more here.
Keywords: cancer; serum igg; hcc; galactosylation ... See more keywords