Galangin attenuates cadmium‐evoked nephrotoxicity: Targeting nucleotide‐binding domain‐like receptor pyrin domain containing 3 inflammasome, nuclear factor erythroid 2‐related factor 2, and nuclear factor kappa B signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23059
Abstract: The kidney is highly vulnerable to cadmium‐evoked oxidative injury. Galangin is a natural flavone with reported antioxidant properties. This study investigated the potential modulating activity of galangin against cadmium‐induced nephrotoxicity and explored the underlining mechanisms.… read more here.
Keywords: nuclear factor; galangin; cadmium evoked; factor ... See more keywords
Galangin controls streptozotocin-caused glucose homeostasis and reverses glycolytic and gluconeogenic enzyme changes in rats
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2018.1498521
Abstract: Abstract Galangin is a natural compound with anticancer, anti-inflammatory, and antioxidant properties. However, the ameliorating effect of streptozotocin (STZ)-induced glucose homeostasis has not yet been evaluated. Hence, this study was aimed at exploring the role… read more here.
Keywords: glucose homeostasis; glycolytic gluconeogenic; gluconeogenic enzyme; galangin ... See more keywords
Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2018.1474931
Abstract: Abstract Context: Galangin, a natural flavonoid, is found in honey and Alpinia officinarum Hance (Zingiberaceae). Galangin has antiviral, antimicrobial, antidiabetic and anticancer properties, without side effects. The effects of galangin on hyperglycaemia and lipid abnormalities… read more here.
Keywords: hyperglycaemia lipid; rats streptozotocin; induced hyperglycaemia; galangin ... See more keywords
A11421 Galangin potentiates remediation of cisplatin-induced nephrotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548244.42193.cf
Abstract: Objectives: Cisplatin is well-known for its wide chemotherapeutic effects but has limited clinical use due to its nephrotoxicity which may lead to cardiac dysfunction or failure. Galangin (3, 5, 7-trihydroxyflavone) extracted from the rhizome of… read more here.
Keywords: induced nephrotoxicity; 100 per; cisplatin induced; galangin ... See more keywords
Galangin suppresses RANKL‐induced osteoclastogenesis via inhibiting MAPK and NF‐κB signalling pathways
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16430
Abstract: Osteoclasts play a critical role in osteoporosis; thus, inhibiting osteoclastogenesis is a therapeutic strategy for osteoporosis. Galangin, a natural bioflavonoid extracted from a traditional Chinese herb, possesses a variety of biological activities, including anti‐inflammation and… read more here.
Keywords: treatment; signalling pathways; mapk signalling; galangin ... See more keywords
Preparation of Prolonged-Circulating Galangin-Loaded Liposomes and Evaluation of Antitumor Efficacy In Vitro and Pharmacokinetics In Vivo
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DOI: 10.1155/2019/7236895
Abstract: Galangin has been reported to have many pharmacological effects including being anti-inflammatory, antibacterial, and antifungal and a suppressor of vitiligo, Alzheimer’s disease, and cancer. The purpose of this research was to characterize and determine the… read more here.
Keywords: loaded liposomes; efficacy; loaded pegylated; galangin ... See more keywords
Galangin reduces vascular endothelial cell dysfunction via Heme oxygenase-1 signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Vascular"
DOI: 10.1177/17085381221084806
Abstract: OBJECTIVE As one of the independent risk factors for atherosclerosis (AS), oxidized low-density lipoprotein (ox-LDL) can trigger damage to the vascular intima and induce the expression of various adhesion molecules. This study aimed to explore… read more here.
Keywords: galangin; oxygenase signaling; signaling pathway; heme oxygenase ... See more keywords
Development and validation of HPTLC fingerprints of three species of Alpinia with biomarker Galangin
Sign Up to like & getrecommendations! Published in 2018 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-017-2033-4
Abstract: BackgroundAlpinia galanga (L.) Willd. commonly called as Rasna, Greater galangal or Kulinjan is a medicinally important rhizome used in Indian traditional system of medicine to cure a number of ailments. A. galanga is the main… read more here.
Keywords: medicine; three species; hptlc; analysis ... See more keywords
Network-based pharmacology and in vitro validation reveal that galangin induces apoptosis in bladder cancer cells by promoting the p53 signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666221026121600
Abstract: BACKGROUND Galangin is one of the flavonoids in alpinia officinarum. It has a variety of anti-tumor activities, but its anti-bladder cancer effect is not clear. AIM OF THE STUDY To investigate the mechanism of action… read more here.
Keywords: galangin; apoptosis; pharmacology; bladder cancer ... See more keywords
Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.646628
Abstract: Galangin, a flavonoid isolated from the rhizome of Alpinia officinarum (Hance), exerts anticancer activities against many cancer cells such as liver cancer, breast cancer, lung cancer and esophageal cancer. However, the effect, as well as… read more here.
Keywords: mgc 803; gastric cancer; stat3; galangin ... See more keywords
Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031387
Abstract: UV radiation and H2O2 are the primary factors that cause skin aging. Both trigger oxidative stress and cellular aging. It has been reported that deacetylase silent information regulator 1 (SIRT1), a longevity gene, enhances activation… read more here.
Keywords: galangin; sirt1 pgc; pgc nrf2; nrf2 signaling ... See more keywords