Dorsal hippocampal galanin modulates anxiety-like behaviours in rats
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.02.036
Abstract: Galanin, a peptide expressed in mammalian brain regions, has been implicated in anxiety and depression. Galanin signalling occurs through three G protein-linked receptors (GAL1, GAL2 and GAL3). Galanin regulates the release of neurotransmitters in some… read more here.
Keywords: dorsal hippocampus; anxiogenic like; like behaviours; behaviours rats ... See more keywords
Hypothalamic Galanin-producing neurons regulate stress in zebrafish through a peptidergic, self-inhibitory loop
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.02.011
Abstract: Animals possess neuronal circuits inducing stress to avoid or cope with threats present in their surroundings, for instance, by promoting behaviors, such as avoidance and escape. However, mechanisms must exist to tightly control responses to… read more here.
Keywords: self inhibitory; galanin; stress; galanin producing ... See more keywords
Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.01.020
Abstract: Objective Decreasing duodenal contraction is now considered as a major focus for the treatment of type 2 diabetes. Therefore, identifying bioactive molecules able to target the enteric nervous system, which controls the motility of intestinal… read more here.
Keywords: duodenal contraction; galanin enhances; metabolism; glucose metabolism ... See more keywords
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0134-3
Abstract: Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while… read more here.
Keywords: protein; biased agonism; conformational signatures; protein coupled ... See more keywords
Galanin contributes to ultraviolet irradiation‐induced inflammation in human skin
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13268
Abstract: Exposure of the skin to ultraviolet (UV) irradiation causes various consequences such as inflammation and photoageing. Galanin is an active neuropeptide expressed widely in the central nervous system and peripheral tissues including the skin. Galanin… read more here.
Keywords: irradiation; ultraviolet irradiation; skin; inflammation ... See more keywords
Galanin inhibition of wake-active histaminergic neurons
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733098
Abstract: Histaminergic neurons are a population of wake-active neurons confined to the tuberomammillary nucleus (TMN) in the posterior hypothalamus. They form a crucial component of the ‘sleep switch’ in the brain and promote arousal when activated.… read more here.
Keywords: hdc; galanin; histaminergic neurons; physiology ... See more keywords
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001714
Abstract: Galanin is a neuropeptide expressed in the central and peripheral nervous systems, where it regulates various processes including neuroendocrine release, cognition, and nerve regeneration. Three G-protein coupled receptors (GPCRs) for galanin have been discovered, which… read more here.
Keywords: structure; galanin; basis ligand; bound galanin ... See more keywords
The galanin and galanin receptor subtypes, its regulatory role in the biological and pathological functions.
Sign Up to like & getrecommendations! Published in 2017 at "Physiological research"
DOI: 10.33549/physiolres.933576
Abstract: The multitalented neuropeptide galanin was first discovered 30 years ago but initially no biologic activity was found. Further research studies discovered the presence of galanin in the brain and some peripheral tissues, and galanin was… read more here.
Keywords: research; galanin galanin; role; galanin ... See more keywords
Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1019943
Abstract: Galanin is a neurohormone as well as a neurotransmitter and plays versatile physiological roles for the neuroendocrine axis, such as regulating food intake, insulin level and somatostatin release. It is expressed in the central nervous… read more here.
Keywords: galanin; spinal cord; galanin family; neuroendocrine axis ... See more keywords
Galanin analogs prevent mortality from seizure-induced respiratory arrest in mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2022.901334
Abstract: Objective Sudden Unexpected Death in Epilepsy (SUDEP) accounts for 20% of mortality in those with recurrent seizures. While risk factors, monitoring systems, and standard practices are in place, the pathophysiology of SUDEP is still not… read more here.
Keywords: seizure induced; galanin analogs; galanin; mortality ... See more keywords
Spinal Cord Injury Causes Reduction of Galanin and Gastrin Releasing Peptide mRNA Expression in the Spinal Ejaculation Generator of Male Rats
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.670536
Abstract: Spinal cord injury (SCI) in men is commonly associated with sexual dysfunction, including anejaculation, and chronic mid-thoracic contusion injury in male rats also impairs ejaculatory reflexes. Ejaculation is controlled by a spinal ejaculation generator consisting… read more here.
Keywords: lst cells; expression; galanin; ejaculation ... See more keywords