Rapid Determination of Galantamine in Human Plasma by Microchip Electrophoresis With a Highly Integrated Contactless Conductivity Detector.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of separation science"
DOI: 10.1002/jssc.70013
Abstract: A novel and rapid method was developed for the determination of galantamine in human plasma by microchip electrophoresis with a highly integrated contactless conductivity detector (CCD). The instrumental parameters affecting the response of the detector,… read more here.
Keywords: human plasma; highly integrated; determination; electrophoresis ... See more keywords
Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4664-z
Abstract: AimIt is widely assumed that the upcoming therapeutics for Alzheimer’s disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase… read more here.
Keywords: allosteric modulator; nicotinic receptor; galantamine; effect ... See more keywords
Galantamine administration reduces reactive astrogliosis and upregulates the anti-oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Developmental Neuroscience"
DOI: 10.1016/j.ijdevneu.2017.07.006
Abstract: Neonatal hypoxia ischemia (HI) plays a role in the etiology of several neurological pathologies and causes severe sequelae. Acetylcholine is a neurotransmitter in the central nervous system and cholinesterase inhibitors have demonstrated a positive action… read more here.
Keywords: hypoxia ischemia; neonatal hypoxia; galantamine; anti oxidant ... See more keywords
Galantamine derivatives: Synthesis, NMR study, DFT calculations and application in asymmetric catalysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128568
Abstract: Abstract In a search of effective ligands for asymmetric catalysis (−)-galantamine has been selected as a complex chiral framework for the synthesis of four novel diphenylphosphino-benzenecarboxamides. Their application in Pd-catalyzed asymmetric allylic alkylation proceeded with… read more here.
Keywords: galantamine; catalysis galantamine; dft calculations; asymmetric catalysis ... See more keywords
Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome.
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DOI: 10.1089/neu.2017.5102
Abstract: Acetylcholine is an excitatory neurotransmitter in the central nervous system that plays a key role in cognitive function, including learning and memory. Previous studies have shown that experimental traumatic brain injury (TBI) reduces cholinergic neurotransmission,… read more here.
Keywords: administration; galantamine; pathology; post injury ... See more keywords
A Randomized Clinical Trial of Oxytocin or Galantamine for the Treatment of Negative Symptoms and Cognitive Impairments in People With Schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000000720
Abstract: Purpose/Background Negative symptoms and cognitive impairments tend to co-occur in people with schizophrenia. If their association with each other is due, in part, to shared pathophysiology, then this suggests that a single drug could potentially… read more here.
Keywords: negative symptoms; galantamine; cognitive impairments; symptoms cognitive ... See more keywords
Acute cholinergic syndrome in a patient with Alzheimer's disease taking the prescribed dose of galantamine
Sign Up to like & getrecommendations! Published in 2018 at "Psychogeriatrics"
DOI: 10.1111/psyg.12341
Abstract: Decreased levels of acetylcholine contribute to cognitive dysfunction in Alzheimer’s disease (AD). Acetylcholinesterase (AChE) inhibitors prevent the degradation of acetylcholine by inhibiting the enzyme AChE, resulting in increased levels of acetylcholine in the synaptic endings.… read more here.
Keywords: galantamine; day; cholinergic syndrome; acute cholinergic ... See more keywords
Galantamine Reduces Blood Pressure and Renal Injury in Female Angiotensin II-induced Hypertensive Mice
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1102
Abstract: Inflammation is a known culprit in the development and progression of hypertension. The autoimmune disease, systemic lupus erythematosus (SLE), is an important model of hypertension in the setting of chronic kidney inflammation. We have shown… read more here.
Keywords: mice; physiology; injury; hypertension ... See more keywords
Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.93340
Abstract: BACKGROUND Metabolic syndrome (MetS) is an obesity-driven condition of pandemic proportions that increases the risk of type 2 diabetes and cardiovascular disease. Pathophysiological mechanisms are poorly understood, though inflammation has been implicated in MetS pathogenesis.… read more here.
Keywords: insulin; trial; galantamine; metabolic syndrome ... See more keywords
Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1141-5
Abstract: BackgroundNeuroinflammation plays an important role in the onset and progression of neurodegenerative diseases such as Alzheimer’s disease. Lipopolysaccharide (LPS, endotoxin) levels are higher in the brains of Alzheimer’s disease patients and are associated with neuroinflammation… read more here.
Keywords: lps induced; galantamine; inflammation; pro inflammatory ... See more keywords
Development and Validation of a UPLC-ESI-MS Method for Quantitation of the Anti-Alzheimer Drug Galantamine and other Amaryllidaceae Alkaloids in Plants
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20190162
Abstract: Our study aimed at the development of a method based on ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-ESI-MS) using selected ion monitoring for the simultaneous quantitation of the alkaloids galantamine, pseudolycorine, sanguinine and narciclasine… read more here.
Keywords: quantitation; galantamine; method; uplc esi ... See more keywords