Exploring the Structural Space of the Galectin‐1–Ligand Interaction
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700251
Abstract: Galectin‐1 is a tumor‐associated protein recognizing the Galβ1‐4GlcNAc motif of cell‐surface glycoconjugates. Herein, we report the stepwise expansion of a multifunctional natural scaffold based on N‐acetyllactosamine (LacNAc). We obtained a LacNAc mimetic equipped with an… read more here.
Keywords: galectin ligand; exploring structural; galectin; structural space ... See more keywords
Sex‐specific associations of cardiorespiratory fitness and galectin‐3 in the general population
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14151
Abstract: Low cardiorespiratory fitness (CRF) is associated with greater mortality and morbidity. Galectin‐3 (Gal‐3) is a prognostic biomarker for fibrosis and heart failure. Gal‐3 is also associated with a greater risk for cardiovascular mortality. Whether CRF… read more here.
Keywords: specific associations; general population; sex specific; galectin ... See more keywords
Galectin‐3 Enhances Osteogenic Differentiation of Precursor Cells From Patients With Diffuse Idiopathic Skeletal Hyperostosis via Wnt/β‐Catenin Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4508
Abstract: Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory skeletal disease characterized by the progressive ectopic ossification and calcification of ligaments and enthuses. However, specific pathogenesis remains unknown. Bone marrow mesenchymal stem cells (BMSCs) are a… read more here.
Keywords: osteogenic differentiation; bmscs; dish bmscs; galectin ... See more keywords
Galectin‐3 as a biomarker in breast neoplasms: Mechanisms and applications in patient care
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5mr0822-673r
Abstract: Galectin‐3 is a member of the lectin family encoded by the LGALS3 gene on chromosome 14. It is secreted by a wide range of immune cells and mammary tumor cells. Through its activity on the… read more here.
Keywords: biomarker; breast; tumor microenvironment; breast neoplasms ... See more keywords
Efficacy of serum apelin and galectin‐3 as potential predictors of mortality in severe COVID‐19 patients
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DOI: 10.1002/jmv.28494
Abstract: Apelin is a cardioprotective biomarker while galectin‐3 is a pro‐inflammatory and profibrotic biomarker. Endothelial dysfunction, hyperinflammation, and pulmonary fibrosis are key mechanisms that contribute to the development of adverse outcomes in Coronavirus disease 2019 (COVID‐19)… read more here.
Keywords: covid patients; severe covid; serum apelin; mortality ... See more keywords
The predictive value of galectin‐3 levels on left atrial low voltage areas assessed by high‐density mapping in patients with paroxysmal atrial fibrillation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Arrhythmia"
DOI: 10.1002/joa3.12703
Abstract: Galectin‐3 is an inflammation biomarker that is associated with atrial fibrosis and plays a role in the development of atrial fibrillation (AF). Low voltage areas (LVAs) identified using an electroanatomical mapping system represent the presence… read more here.
Keywords: galectin levels; patients paroxysmal; low voltage; voltage areas ... See more keywords
Genetic determinants of circulating galectin‐3 levels in patients with coronary artery disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1370
Abstract: Galectin‐3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin‐3 levels, and inflammatory marker levels in patients with coronary artery disease… read more here.
Keywords: levels patients; patients coronary; galectin; coronary artery ... See more keywords
Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pediatrics"
DOI: 10.1007/s00431-017-3079-5
Abstract: Galectin-3 has recently been proposed as a novel biomarker for cardiovascular disease in adults. The purpose of this investigation was to assess relationships between galectin-3 levels and total body fat, abdominal fat, body fat distribution,… read more here.
Keywords: total body; galectin; abdominal fat; body fat ... See more keywords
Different angioregulatory activity of monovalent galectin-9 isoforms
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DOI: 10.1007/s10456-018-9607-8
Abstract: Galectin-9 consists of two peptide-linked carbohydrate recognition domains (CRDs), but alternative splicing and proteolytic processing can give rise to multiple galectin-9 isoforms. Some of these consist of a single CRD and can exert different functions… read more here.
Keywords: cell biology; endothelial cell; galectin isoforms; galectin ... See more keywords
Cleavage and phosphorylation: important post-translational modifications of galectin-3
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DOI: 10.1007/s10555-017-9666-0
Abstract: As the unique chimeric member of the β-galactoside-binding protein family, galectin-3 is a multivalent and multifunctional oncogenic protein involved in multiple physiological and pathological processes, including cell growth, cell differentiation, cell adhesion, RNA splicing, cell… read more here.
Keywords: galectin; post translational; cleavage phosphorylation; translational modifications ... See more keywords
Neuroanatomical distribution of galectin-3 in the adult rat brain
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-017-9712-9
Abstract: Galectin-3 is a member of the lectin subfamily that enables the specific binding of β-galactosides. It is expressed in a broad spectrum of species and organs, and is known to have various functions related to… read more here.
Keywords: rat brain; expression; distribution galectin; galectin ... See more keywords