NLRP3 is dispensable for d-galactosamine/lipopolysaccharide-induced acute liver failure.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.10.003
Abstract: The nucleotide-binding domain and leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome is involved in various acute and chronic liver diseases, however, it is not clear whether NLRP3 contributes to d-Galactosamine (D-GalN) plus lipopolysaccharide… read more here.
Keywords: lps induced; liver; mice; galn lps ... See more keywords
Polyphenols from Morchella angusticepes Peck attenuate D-galactosamine/lipopolysaccharide-induced acute hepatic failture in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.04.064
Abstract: Abstract We investigated the effect of polyphenols extracted from M. angusticepes Peck (PMP) on D-galactosamine/lipopolysaccharide (D-GalN/LPS) induced acute hepatic failure (AHF) in mice. Results indicated that administration of PMP relieved the leakage of serum alanine… read more here.
Keywords: angusticepes peck; mice; acute hepatic; induced acute ... See more keywords
Inhibition of O-glycosylation aggravates GalN/LPS-induced liver injury through activation of ER stress.
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2021.1979035
Abstract: OBJECTIVE O-glycosylation is the most common post-translational modification of proteins, which is involved in many pathophysiological processes including inflammation. Acute liver injury is characterized by an excessive, uncontrolled inflammatory response, but the effects of aberrant… read more here.
Keywords: benzyl galnac; lps induced; stress; glycosylation ... See more keywords
Microbial metabolites indole derivatives sensitize mice to D-GalN/LPS induced-acute liver failure via the Tlr2/NF-κB pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1103998
Abstract: Introduction Acute liver failure (ALF) is a clinical condition with many causes, fast progression, and a poor prognosis. Previous research has indicated that microbial factors have a role in ALF, but a clear picture has… read more here.
Keywords: microbial metabolites; indole derivatives; acute liver; galn lps ... See more keywords
Maresin1 Protect Against Ferroptosis-Induced Liver Injury Through ROS Inhibition and Nrf2/HO-1/GPX4 Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.865689
Abstract: Drugs, viruses, and chemical poisons stimulating live in a short period of time can cause acute liver injury (ALI). ALI can further develop into serious liver diseases such as cirrhosis and liver cancer. Therefore, how… read more here.
Keywords: mar1 inhibited; liver injury; galn lps; induced liver ... See more keywords
Levosimendan Increases Survival in a D-Galactosamine and Lipopolysaccharide Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123161
Abstract: Levosimendan, a calcium sensitizer, has an organ protective profile through the inhibition of inflammatory mediators and cytokines in critical conditions, such as heart failure, ischemia-reperfusion injury, and sepsis. The survival effect of levosimendan for acute… read more here.
Keywords: model levosimendan; levosimendan; galn lps; levosimendan increases ... See more keywords