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Published in 2019 at "Current Protocols in Nucleic Acid Chemistry"
DOI: 10.1002/cpnc.99
Abstract: Ligand‐targeted drug delivery (LTDD) has emerged as an attractive option in the field of oligonucleotide drugs following the great success of N‐acetylgalactosamine (GalNAc)–conjugated siRNA and antisense oligonucleotides. GalNAc is a well‐known ligand of the asialoglycoprotein…
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Keywords:
acetylgalactosamine;
galnac;
moiety;
monovalent ... See more keywords
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Published in 2021 at "Carbohydrate research"
DOI: 10.1016/j.carres.2021.108495
Abstract: Mucin-type O-glycosylation of serine or threonine residue in proteins is known to be one of the major post-translational modifications. In this study, two novel alkyl glycosides, Nα-lauryl-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l-serineamide (GalNAc-Ser-C12) and Nα-lauryl-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l-threonineamide (GalNAc-Thr-C12) were synthesized as saccharide…
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Keywords:
galnac;
galnac ser;
saccharide primers;
mucin type ... See more keywords
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Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.10.001
Abstract: ABSTRACT RNA interference (RNAi) has the potential to reversibly silence any gene with high efficiency and specificity. To fulfill the clinical potential of RNAi, delivery vehicles are required to transport the short interfering RNA (siRNA)…
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Keywords:
surface;
functionalization nanoparticles;
bio functionalization;
galnac ... See more keywords
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Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01337
Abstract: Conjugation of synthetic triantennary N-acetyl-d-galactosamine (GalNAc) to small interfering RNA (siRNA) mediates binding to the asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes, facilitating liver-specific uptake and siRNA-mediated gene silencing. The natural β-glycosidic bond of…
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Keywords:
anomeric linkages;
sirna;
galnac sirna;
glycosidase ... See more keywords
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Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00498
Abstract: Campylobacter jejuni is a significant cause of human gastroenteritis worldwide, and all strains express an N-glycan that is added to at least 80 different proteins. We characterized 98 C. jejuni isolates from infants from 7…
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Keywords:
campylobacter jejuni;
detecting glucose;
glucose fluctuations;
galnac galnac ... See more keywords
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Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04477
Abstract: Glycosylation is a vital post-translational modification involved in a range of biological processes including protein folding, signaling, and cell-cell interactions. In 2011, a new type of O-linked glycosylation was discovered, wherein the side-chain oxygen of…
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Keywords:
tyrosine;
cell;
galnac;
galnac tyr ... See more keywords
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Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1902211116
Abstract: Significance While it is well established that heavily O-glycosylated mucins are essential for normal gastrointestinal function, it is not known how polypeptide N-acetylgalactosaminyl transferase (GalNAc-T12)–specific O-glycans may be contributing. Here we use structural, computational, and…
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Keywords:
galnac t12;
function;
colorectal cancer;
galnac ... See more keywords
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Published in 2018 at "Toxicologic Pathology"
DOI: 10.1177/0192623318792537
Abstract: Short interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs) are the most clinically advanced oligonucleotide-based platforms. A number of N-acetylgalactosamine (GalNAc)-conjugated siRNAs (GalNAc-siRNAs), also referred to as RNA interference (RNAi) therapeutics, are currently in various stages…
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Keywords:
rnai therapeutics;
galnac conjugated;
safety;
galnac sirnas ... See more keywords
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Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0179241
Abstract: Mucin-type O-glycosylation is initiated by the UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Their activity results in the GalNAc α1-O-Thr/Ser structure, termed the Tn antigen, which is further decorated with additional sugars. In neoplastic cells, the…
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Keywords:
golgi complex;
mechanism;
mucin type;
type glycosylation ... See more keywords
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Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1029911
Abstract: Structures containing galactose and GalNAc residues are specifically recognized by asialoglycoprotein receptors, allowing them to selectively internalize by hepatocytes for drug-targeting delivery. However, methods for direct synthesis of GalNAc glycosides are still challenging due to…
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Keywords:
synthesis;
earth metal;
rare earth;
metal triflates ... See more keywords
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Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10040636
Abstract: Bovine submaxillary mucin (BSM) is a gel-forming glycoprotein polymer, and Ser/Thr-linked glycans (O-glycans) are important in regulating BSM’s viscoelasticity and polymerization. However, details of O-glycosylation have not been reported. This study investigates the structural and…
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Keywords:
bovine submaxillary;
submaxillary mucin;
glycosylation;
galnac ... See more keywords