The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function
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DOI: 10.1073/pnas.1902211116
Abstract: Significance While it is well established that heavily O-glycosylated mucins are essential for normal gastrointestinal function, it is not known how polypeptide N-acetylgalactosaminyl transferase (GalNAc-T12)–specific O-glycans may be contributing. Here we use structural, computational, and… read more here.
Keywords: galnac t12; function; colorectal cancer; galnac ... See more keywords