Stable Regulation of Senescence-Related Genes in Galactose-alpha1,3-galactose Epitope Knockout and Human Membrane Cofactor Protein hCD46 Pig.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.03.028
Abstract: BACKGROUND Pigs are considered suitable animal donor models for xenotransplantation. For successful organ transplantation, immune rejection must be overcome. Xenotransplantation has recently been successfully performed using galactose-alpha1,3-galactose epitopes knockout (GalTKO) and a human membrane cofactor… read more here.
Keywords: pig; hcd46; related genes; galtko hcd46 ... See more keywords
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.
Sign Up to like & getrecommendations! Published in 2022 at "Xenotransplantation"
DOI: 10.1111/xen.12725
Abstract: BACKGROUND Loss of barrier function when GalTKO.hCD46 porcine lungs are perfused with human blood is associated with coagulation pathway dysregulation, innate immune system activation, and rapid sequestration of human formed blood elements. Here, we evaluate… read more here.
Keywords: lung; galtko hcd46; htfpi hcd47; selectin integrin ... See more keywords
hEPCR.hTBM.hCD47.hHO-1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood.
Sign Up to like & getrecommendations! Published in 2022 at "Xenotransplantation"
DOI: 10.1111/xen.12731
Abstract: INTRODUCTION Platelet sequestration, inflammation, and inappropriate coagulation cascade activation are prominent in liver xenotransplant models and are associated with poor outcomes. Here, we evaluate a cassette of six additional genetic modifications to reduce anti-pig antibody… read more here.
Keywords: htbm hcd47; galtko hcd46; hho; gene ... See more keywords