Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115110
Abstract: Melanoma is characterized by high malignancy and early onset of metastasis. Epithelial-to-mesenchymal transition (EMT) is an early event during tumor metastasis. Tumor cells that develop EMT can escape apoptosis, but they are vulnerable to ferroptosis… read more here.
Keywords: melanoma; mesenchymal transition; induces ferroptosis; melanoma cells ... See more keywords
Self-assembled micelles based on gambogenic acid-phospholipid complex for sustained-release drug delivery
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2019.1656294
Abstract: Abstract Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can… read more here.
Keywords: gna plc; gna; plc micelles; sustained release ... See more keywords
Gambogenic acid inhibits the proliferation of small-cell lung cancer cells by arresting the cell cycle and inducing apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Reports"
DOI: 10.3892/or.2018.6950
Abstract: Gambogenic acid (GNA), which is an important active compound present in gamboge, exerts anticancer activity in various types of tumor cells. However, the effect of GNA on small-cell lung cancer (SCLC) cell lines and the… read more here.
Keywords: apoptosis; gna; cell cycle; gambogenic acid ... See more keywords
Gambogenic Acid Exerts Antitumor Activity in Hypoxic Multiple Myeloma Cells by Regulation of miR-21
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer"
DOI: 10.7150/jca.19290
Abstract: Hypoxia is an inseparable component of the bone marrow (BM) microenvironment, accounting for aggressive tumor behavior and poor prognosis of multiple myeloma (MM). Gambogenic acid (GNA) has proven to be an attractive option for treatment… read more here.
Keywords: multiple myeloma; gambogenic acid; hypoxia; activity ... See more keywords