Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
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DOI: 10.1038/ncomms15160
Abstract: Plasmodium falciparum stage V gametocytes are responsible for parasite transmission, and drugs targeting this stage are needed to support malaria elimination. We here screen the Tres Cantos Antimalarial Set (TCAMS) using the previously developed P.… read more here.
Keywords: gametocyte; hundreds dual; antimalarial molecules; gametocyte screen ... See more keywords
Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness
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DOI: 10.1186/s12936-021-03855-3
Abstract: Background Seasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period. Whether the addition of azithromycin (AZ) to SMC could potentiate the benefit of… read more here.
Keywords: addition; transmission; gametocyte; falciparum ... See more keywords
Predominance of asymptomatic and sub-microscopic infections characterizes the Plasmodium gametocyte reservoir in the Peruvian Amazon
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005674
Abstract: Malaria transmission requires that Anopheles mosquitoes ingest Plasmodium gametocyte stages circulating in the human bloodstream. In the context of malaria elimination, understanding the epidemiology of gametocytes relative to all Plasmodium infections and the contribution of… read more here.
Keywords: plasmodium; asymptomatic sub; sub microscopic; gametocyte ... See more keywords
Identification of the asymptomatic Plasmodium falciparum and Plasmodium vivax gametocyte reservoir under different transmission intensities
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DOI: 10.1371/journal.pntd.0009672
Abstract: Background Understanding epidemiological variables affecting gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission. Methodology/Principal findings Plasmodium falciparum and P. vivax parasites and gametocytes were quantified by qPCR… read more here.
Keywords: microscopy; transmission; gametocyte; falciparum ... See more keywords
Seasonal variations in Plasmodium falciparum parasite prevalence assessed by varying diagnostic tests in asymptomatic children in southern Ghana
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DOI: 10.1371/journal.pone.0199172
Abstract: Plasmodium falciparum infections presenting either as symptomatic or asymptomatic may contain sexual stage parasites (gametocytes) that are crucial to malaria transmission. In this study, the prevalence of microscopic and submicroscopic asexual and gametocyte parasite stages… read more here.
Keywords: gametocyte; southern ghana; prevalence; pcr ... See more keywords
Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.934641
Abstract: Despite significant developments towards malaria reduction, parasite transmission in the common context of HIV-1 co-infection and treatment for one or both infections has not been fully characterized. This is particularly important given that HIV-1 and… read more here.
Keywords: gametocyte; hiv; transcript; infection ... See more keywords
The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.930956
Abstract: Individuals infected with P. falciparum develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes. However, there is currently limited knowledge on the immunogenicity of gametocyte antigens… read more here.
Keywords: gametocyte; controlled human; infection; human malaria ... See more keywords