Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.
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DOI: 10.1158/0008-5472.can-16-3424
Abstract: Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and inhibition… read more here.
Keywords: cancer; gamitrinib tpp; bcl family; mitochondrial matrix ... See more keywords